摘要
目的探讨唾液褪黑素在2型糖尿病(T2DM)合并慢性牙周炎(CP)患者中的临床意义。方法选取2022年10月至2023年3月在该院内分泌科及口腔科就诊的85例患者作为研究对象,按照疾病类型分为CP组(28例)、T2DM组(27例)、T2DM伴CP组(30例)。另选取同期在该院体检中心体检的30例健康者作为健康对照组。让所有研究对象填写一般情况调查表、糖尿病患者生存质量特异性量表(DSQL)及口腔健康影响程度量表(OHIP-14),进行牙周检查及唾液褪黑素水平检测,并收集T2DM患者的空腹血糖、糖化血红蛋白水平及体质量指数,并对收集的数据进行统计分析。采用Pearson相关分析4组唾液褪黑素水平与牙周指标的相关性。结果CP组及T2DM伴CP组的牙龈出血指数、探诊深度、临床附着丧失均大于健康对照组及T2DM组,差异均有统计学意义(P<0.05)。T2DM伴CP组的探诊深度大于CP组(P<0.05)。T2DM伴CP组的糖化血红蛋白水平、体质量指数、DSQL得分及OHIP-14得分均高于T2DM组,差异均有统计学意义(P<0.05)。健康对照组的唾液褪黑素水平高于CP组、T2DM组及T2DM伴CP组,差异均有统计学意义(Z=3.860、3.014、6.490,P=0.010、0.015、<0.001)。T2DM伴CP组唾液褪黑素水平低于T2DM组(Z=3.302,P=0.006)。Pearson相关分析结果显示,CP组及T2DM伴CP组唾液褪黑素水平与临床附着丧失均呈负相关(r=-0.820、-0.662,P<0.05)。结论CP患者及T2DM合并CP患者的唾液褪黑素水平与临床附着丧失呈负相关,可通过无创检测唾液的褪黑素水平辅助临床评估CP患者及T2DM合并CP患者的治疗效果,为维持牙周健康提供新思路。
Objective To investigate the clinical significance of salivate melatonin in patients with type 2 diabetes mellitus(T2DM)and chronic periodontitis(CP).Methods A total of 85 patients in the Department of Endocrinology and Stomatology of the hospital from October 2022 to March 2023 were selected as the study objects and were divided into CP group(28 cases),T2DM group(27 cases)and T2DM with CP group(30 cases)according to disease types.In addition,30 healthy people who underwent physical examination in the physical examination center of the hospital were selected as the healthy control group.All subjects completed the general information questionnaire,Diabetes-Specific Quality of Life scale(DSQL),Oral Health Impact Profile scale(OHIP-14),periodontal examination and salivate melatonin test.The fasting blood glucose,glycosylated hemoglobin and body mass index of T2DM patients were collected.Then the collected data were statistically analyzed.Pearson correlation analysis was used to analyze the correlation between salivary melatonin levels and periodontal parameters in the four groups.Results The gingival bleeding index,probing depth and clinical attachment loss of the CP group and the T2DM with CP group were higher than those of the healthy control group and the T2DM group,and the differences were statistically significant(P<0.05).The probing depth of the T2DM with CP group was higher than that of the CP group(P<0.05).The glycosylated hemoglobin level,body mass index,DSQL score and OHIP-14 score of the T2DM with CP group were higher than those of the T2DM group,and the differences were statistically significant(P<0.05).The salivate melatonin level of the healthy control group was higher than that of the CP group,the T2DM group and the T2DM with CP group,and the differences were statistically significant(Z=3.860,3.014,6.490,P=0.010,0.015,<0.001).The level of salivate melatonin in the T2DM with CP group was lower than that in the T2DM group(Z=3.302,P=0.006).Pearson correlation analysis showed that salivate melatonin level
作者
王祥雨
仇彩霞
丁红忠
WANG Xiangyu;QIU Caixia;DING Hongzhong(Department of Stomatology,Affiliated Chaohu Hospital of Anhui Medical University,Chaohu,Anhui 238000,China;Department of Endocrinology,Affiliated Chaohu Hospital of Anhui Medical University,Chaohu,Anhui 238000,China)
出处
《检验医学与临床》
CAS
2024年第11期1611-1616,共6页
Laboratory Medicine and Clinic
基金
安徽医科大学附属巢湖医院科研基金项目(2018ykj010)。
关键词
唾液
褪黑素
慢性牙周炎
糖尿病
口腔健康
saliva
melatonin
chronic periodontitis
diabetes mellitus
oral health
