摘要
目的对吲哚布芬对比阿司匹林在治疗急性缺血性脑卒中患者的有效性和安全性进行Meta分析。方法检索中国知网、万方数据库、PubMed、Cochrane Library、Embase,收集吲哚布芬(试验组)对比阿司匹林(对照组)的随机对照研究,检索时限为建库至2023年4月20日。由2名研究者根据纳入和排除标准独立筛选文献、提取资料并评价纳入研究的质量,使用RevMan 5.4软件进行Meta分析。结果Meta分析结果显示:吲哚布芬组中总不良反应发生率低于阿司匹林组[RR=0.28,95%CI(0.14,0.56),P=0.0003];2组美国国立卫生研究院卒中量表(NIHSS)评分[MD=-1.30,95%CI(-2.97,0.38),P=0.13]、花生四烯酸(AA)诱导的血小板聚集率[MD=-1.70,95%CI(-5.76,2.37),P=0.41]、二磷酸腺苷(ADP)诱导的血小板聚集率[MD=-1.76,95%CI(-7.41,3.90),P=0.54]、临床总有效率[RR=1.05,95%CI(0.97,1.13),P=0.26]差异无统计学意义。结论抗血小板聚集药物吲哚布芬与阿司匹林治疗急性缺血性脑卒中患者的临床疗效相似,但吲哚布芬在治疗缺血性脑卒中的胃肠道反应、头晕、出血、皮疹等不良反应事件的发生率低于阿司匹林。
Objective A meta-analysis of the efficacy and safety of indobufen compared to aspirin in treating patients with acute ischemic stroke.Methods The databases including CNKI,Wanfang Data,PubMed,Cochrane Library and Embase were searched for the randomized controlled trials about indobufen(trial group)and aspirin(control group)were collected from the inception to April 20,2023.According to the inclusion and exclusion criteria,two researchers independently screened the literature,extracted the data and evaluated the quality of the included studies,and used RevMan 5.4 software for Meta-analysis.Results Meta-analysis showed that the total adverse reaction rate of trial group lower than control group[RR(95%CI):0.28(0.14,0.56),P=0.0003].There was no significant difference of the two groups in NIHSS score[MD(95%CI):-1.30(-2.97,0.38),P=0.13],rate of platelet aggregation induced by AA[MD(95%CI):-1.70(-5.76,2.37),P=0.41],rate of platelet aggregation induced by ADP[MD(95%CI):-1.76(-7.41,3.90),P=54],total clinical effective rate[RR(95%CI):1.05(0.97,1.13),P=0.26].Conclusion Indobufen has similar clinical efficacy to aspirin in the treatment of patients with acute ischemic stroke however,the incidence of indobufen was significantly lower than that of aspirin in gastrointestinal reactions,dizziness,bleeding,rash and other adverse events.
作者
张志勇
郭浩
杨宏昕
Zhang Zhiyong;Guo Hao;Yang Hongxin(School of Pharmacy,Baotou Medical College,Baotou,Inner Mongolia 014040,China;Department of Pharmacy,Inner Mongolia People′s Hospital,Hohhot,Inner Mongolia,010017,China)
出处
《中国药物与临床》
CAS
2024年第6期369-374,F0003,共7页
Chinese Remedies & Clinics
基金
内蒙古自治区人民医院院内基金项目(2020YN23)。
关键词
吲哚布芬
阿司匹林
卒中
脑梗死
META分析
Indobufen
Aspirin,Acute ischemic stroke
Cerebral infarction
Meta-analysis
