摘要
目的:观察盐酸二甲双胍缓释片联合门冬胰岛素30注射液治疗妊娠期糖尿病(GDM)患者的效果。方法:选取2021年1月至2023年2月该院收治的182例GDM患者进行前瞻性研究,按照抛硬币法分为观察组与对照组各91例。对照组采用门冬胰岛素30注射液治疗,观察组在对照组基础上联合盐酸二甲双胍缓释片治疗,比较两组流产率、自然分娩率、剖宫产率以及分娩成功患者血糖指标[空腹血糖、餐后2 h血糖(2hPG)]水平、空腹胰岛素水平和脂肪细胞因子(脂联素、瘦素)水平。结果:观察组自然分娩率为81.32%,高于对照组的54.95%,差异有统计学意义(P<0.05);观察组剖宫产率为15.38%,低于对照组的39.56%,差异有统计学意义(P<0.05);分娩后,两组分娩成功患者脂联素水平高于治疗前,且观察组高于对照组,空腹血糖、2hPG、空腹胰岛素和瘦素水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);两组流产率比较,差异无统计学意义(P>0.05)。结论:盐酸二甲双胍缓释片联合门冬胰岛素30注射液治疗GDM患者可提高自然分娩率,改善分娩成功患者脂肪细胞因子水平,以及降低剖宫产率、分娩成功患者血糖指标水平和空腹胰岛素水平,效果优于单纯门冬胰岛素30注射液治疗。
Objective:To observe effects of Metformin hydrochloride sustained-release tablets combined with Insulin aspart 30 injection in treatment of gestational diabetes mellitus(GDM).Methods:A prospective study was conducted on 182 patients with GDM admitted to the hospital from January 2021 to February 2023.According to the coin tossing method,they were divided into observation group and control group,91 cases in each group.The control group was treated with Insulin aspart 30 injection,while the observation group was treated with Metformin hydrochloride sustained-release tablets on the basis of that of the control group.The abortion rate,the natural delivery rate,the cesarean section rate,the blood glucose index[fasting blood glucose,2 h postprandial blood glucose(2hPG)]levels,the fasting insulin level,and the adipocytokines(adiponectin,leptin)level were compared between the two groups.Results:The natural delivery rate of the observation group was 81.32%,which was higher than 54.95%of the control group,and the difference was statistically significant(P<0.05).The cesarean section rate of the observation group was 15.38%,which was lower than 39.56%of the control group,and the difference was statistically significant(P<0.05).After delivery,the levels of adiponectin in the two groups of patients with successful delivery were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of fasting blood glucose,2hPG,fasting insulin and leptin were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the abortion rate between the two groups(P>0.05).Conclusions:Metformin hydrochloride sustained-release tablets combined with Insulin aspart 30 injection in the treatment of the GDM patients can improve the natural delivery rate,improve the levels of adipocytokines in the patients with successful deliv
作者
贾照平
JIA Zhaoping(Department of Obstetrics of Nanyang Wolong District Maternal and Child Health Hospital,Nanyang 473000 Henan,China)
出处
《中国民康医学》
2024年第10期76-78,共3页
Medical Journal of Chinese People’s Health
