摘要
目的研究表皮生长因子受体(EGFR)、过氧化物还原蛋白4(PRDX4)、葡萄糖转运蛋白-1(GLUT-1)在口腔鳞癌(OSCC)组织中的表达水平及其临床意义。方法选取口腔鳞癌患者74例,比较其癌组织和癌旁正常组织EGFR、PRDX4、GLUT-1 mRNA和蛋白表达情况,分析三者表达水平的相关性,以及其与OSCC病理特征、患者生存时间的关系。结果OSCC癌组织中EGFR、PRDX4、GLUT-1 mRNA水平及蛋白阳性表达率高于癌旁正常组织(P<0.05)。OSCC患者组织EGFR、PRDX4、GLUT-1表达水平互相呈正相关(P<0.001)。低分化程度、有淋巴结转移、Ⅲ期~Ⅳ期患者EGFR、PRDX4和GLUT-1阳性表达率较高(P<0.05)。EGFR、PRDX4、GLUT-1阳性表达者总生存率低于阴性表达者(P<0.05)。结论OSCC癌组织EGFR、PRDX4、GLUT-1表达水平明显升高,且与临床病理参数及生存时间紧密相关,可能参与OSCC的发生发展。
Aim To study the expression levels and clinical significance of epidermal growth factor receptor(EGFR),peroxiredoxin 4(PRDX4)and glucose transporter-1(GLUT-1)in oral squamous cell carcinoma tissues.Methods 74 patients with oral squamous cell carcinoma(OSCC)were selected.The mRNA and protein expression levels of EGFR,PRDX4 and GLUT-1 in cancer tissues and adjacent normal tissues were compared,and the correlation among the expression levels of the three indicators as well as the relationship with pathological characteristics and survival time of OSCC patients were analyzed.Results The mRNA expression and protein positive expression rate levels of EGFR,PRDX4 and GLUT-1 in OSCC cancer tissues were higher than those in adjacent normal tissues(P<0.05).The expression levels of EGFR,PRDX4,and GLUT-1 in OSCC tissues were positively correlated with each other(P<0.001).The positive expression rates of EGFR,PRDX4 and GLUT-1 were higher in patients with low differentiation degree,lymph node metastasis and stageⅢ-Ⅳ(P<0.05).The overall survival rate of patients with positive expressions of EGFR,PRDX4 and GLUT-1 was significantly lower than that of patients with negative expressions(P<0.05).Conclusion The expression levels of EGFR,PRDX4 and GLUT-1 in OSCC tissues are significantly increased,and are closely related to clinicopathological parameters and survival time of patients,which may be involved in the occurrence and development of OSCC.
作者
王丹
张洁
刘辉勇
WANG Dan;ZHANG Jie;LIU Huiyong(Department of Stomatology,Huangzhou District People's Hospital of Huanggang,Huanggang 438000,Hubei,China)
出处
《中南医学科学杂志》
CAS
2024年第3期456-459,共4页
Medical Science Journal of Central South China
