摘要
糖尿病是一种以血糖增高为主要特征的代谢性疾病,常导致患者骨代谢异常。如何促进糖尿病患者骨缺损的修复是目前临床亟须解决的问题。利拉鲁肽是一种新型GLP-1类抗糖尿病药物,目前已在糖尿病治疗过程中广泛应用。近年来,大量基础研究和临床实践证据表明,利拉鲁肽能够通过多种途径稳定全身血糖水平、调节骨代谢、促进血管形成、调控免疫反应,从而加速糖尿病患者骨缺损的修复。本文将综述利拉鲁肽在调控骨代谢、血管形成、免疫反应等中的作用及作用机制,为利拉鲁肽的临床应用和糖尿病患者骨缺损的修复提供新的思路。
Diabetes mellitus is a metabolic disease characterized by increased blood glucose,which often leads to abnormal bone metabolism,thereby increasing the risk of fracture and seriously affecting the process of tissue repair after bone defects in patients.How to promote the repair of bone defects in diabetic patients is an urgent clinical problem.Liraglutide is a new type of GLP-1 anti-diabetic drug,which has been widely used in the diabetes treatment.In recent years,a large amount of basic research and clinical evidence have shown that liraglutide can accelerate the repair of bone defects in diabetic patients by stabilizing systemic blood glucose levels,regulating bone metabolism,promoting angiogenesis,and modulating immune responses through various pathways.In this review,we will discuss the role of liraglutide in regulating bone metabolism,blood vessel formation and immune response as well as its mechanism of action and provide new ideas for the clinical use of liraglutide and the repair of bone defects in diabetic patients.
作者
何奕琳
马瑞洪
郜康
窦一萍
宋文鹏
马攀
HE Yi-lin;MA Rui-hong;GAO Kang;DOU Yi-ping;SONG Wen-peng;MA Pan(Department of Dental Implant Center,Beijing Stomatological Hospital,School of Stomatology,Capital Medical University,Beijing 100050,China;Beijing Laboratory of Oral Health,Capital Medical University,Beijing 100069,China;Department of Geriatric Sto-matology,Beijing Stomatological Hospital,School of Stomatology,Capital Medical University,Beijing 100050,China;Department of Stomatology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《口腔颌面修复学杂志》
2024年第3期228-233,共6页
Chinese Journal of Prosthodontics
基金
国家自然科学基金资助项目(项目编号:81974153)。
关键词
利拉鲁肽
糖尿病
骨缺损
骨免疫
liraglutide
diabetes
bone defect
bone immunity
