摘要
目的:分析泉州地区献血者细小病毒B19感染的发生情况及其特点,为临床的用血安全提供参考。方法:选取2021年10月—2022年4月泉州市中心血站采集到的5026份献血者的献血血样作为研究资料,对其进行细小病毒B19的核酸试验筛检(nucleic acid testing,NAT),随后再随机抽取800份血样进行细小病毒B19的免疫球蛋白G(immunoglobulin G,IgG)和免疫球蛋白M(immunoglobulin M,IgM)抗体检测,分析献血者细小病毒B19感染的发生情况及其特点。结果:5026份献血者血样的细小病毒B19的NAT结果均为阴性,阴性率为100.00%;800份血样的细小病毒B19抗体检测结果显示,有134份的抗体检测结果为阳性(阳性率为16.75%),其中IgG阳性111份、IgM阳性有28份(IgG、IgM双阳的有5份);流行病学分析显示,女性、>35~45岁群体、山区人民和农民的抗体阳性率较高(P<0.05)。结论:此次泉州地区献血者的血样并未检出细小病毒B19感染的情况,但鉴于抗体检查中有部分样品呈阳性,血站仍有进行常态化检查的必要,以确保患者的用血安全。
Objective:To analyze the occurrence and characteristics of parvovirus B19 infection in blood donors in Quanzhou area,and provide reference for clinical blood use safety.Methods:A total of 5026 blood samples collected from blood donors in Quanzhou Central Blood Station from October 2021 to April 2022 were selected as research data for nucleic acid testing(NAT)of parvovirus B19.Subsequently,800 blood samples were randomly selected for testing for immunoglobulin G(IgG)and immunoglobulin M(IgM)antibodies against parvovirus B19,and the occurrence and characteristics of parvovirus B19 infection in blood donors were analyzed.Results:The NAT results of parvovirus B19 in 5026 blood samples from blood donors were all negative,with a negative rate of 100.00%;the testing results of parvovirus B19 antibodies in 800 blood samples showed that 134 of them were positive(with a positive rate of 16.75%),of which 111 were IgG positive and 28 were IgM positive(5 were both IgG and IgM positive);epidemiological analysis showed that the antibody positive rate was higher among women,the population aged over 35-45,people in mountainous areas,and farmers(P<0.05).Conclusion:No parvovirus B19 infection is detected in the blood samples from blood donors in Quanzhou area this time.However,considering that some samples are positive in antibody test,it is still necessary for the blood station to conduct regular tests to ensure the blood use safety of patients.
作者
张璇
王文杰
林奕丽
ZHANG Xuan;WANG Wen-jie;LIN Yi-li(Laboratory Department of Quanzhou Central Blood Station,Quanzhou Fujian 362000,China)
出处
《抗感染药学》
2024年第3期256-259,共4页
Anti-infection Pharmacy
基金
福建省泉州市科技计划项目(编号:2020N66S)。
关键词
细小病毒B19感染
献血者
流行病学特点
核酸试验筛检
泉州地区
parvovirus B19 infection
blood donors
epidemiological characteristics
nucleic acid test screening
Quanzhou area
