摘要
氧化应激与各种因素导致的女性生育力下降密切相关。抗氧化剂能拮抗氧化应激的作用,被越来越多地用于生育力低下女性的辅助治疗。然而,抗氧化剂能否提高生育力低下女性的生育力,改善其妊娠结局,临床上相关研究较少,且质量较低,结论不一。该文就氧化应激对女性生育力的影响,以及抗氧化剂在多囊卵巢综合征、子宫内膜异位症、不明原因性不孕等常见的导致女性生育力下降,且与氧化应激密切相关疾病中的应用研究进展进行了综述,旨在为临床治疗提供依据。
Oxidative stress is closely linked to the decline inof female fertility caused by various factors.Antioxidants,which can counteract oxidative stress,have been increasingly used as adjunctive therapy for women with reduced fertility.However,there are limited clinical studies on whether antioxidants can enhance fertility in women with low reproductive capacity and improve pregnancy outcomes,with inconsistent results and generally low-quality evidence.This paper reviewed the impact of oxidative stress on female fertility and discusses the progress of research on the application of antioxidants in common conditions that lead to reduced female fertility and are closely associated with oxidative stress,such as polycystic ovary syndrome,endometriosis,and unexplained infertility,aiming to provide a reference for clinical treatment.
作者
覃金春(综述)
覃捷(审校)
QIN Jinchun;QIN Jie(Reproductive Medicine and Genetics Center,People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530021,China)
出处
《现代医药卫生》
2024年第10期1773-1776,共4页
Journal of Modern Medicine & Health
基金
广西壮族自治区自然科学基金项目(2022JJA140404)
广西壮族自治区卫生健康委员会自筹课题(Z-20201059)。
关键词
氧化应激
抗氧化剂
低生育力
女性
综述
Oxidative stress
Antioxidant
Low fertility
Female
Review
