摘要
目的 观察经皮耳甲迷走神经刺激(taVNS)治疗慢性意识障碍(pDoC)的临床效果。方法选取宝鸡第三医院2020-06—2022-12收治的68例pDoC患者,随机分成对照组与治疗组各34例。对照组接受常规促醒治疗,治疗组在对照组的基础上接受taVNS治疗,2组患者均治疗4周。对比2组患者格拉斯哥昏迷量表(GCS)评分、昏迷恢复量表(CRS-R)评分、全身无反应性量表(FOUR)评分、安全性及临床疗效。结果 治疗后,2组患者的GCS单项评分(睁眼、言语和运动)及总分、CRS-R单项评分(听觉、视觉、运动、言语、交流和唤醒)及总分和FOUR单项评分(眼部、运动、脑干和呼吸)及总分均升高(均P<0.05),且治疗组GCS单项评分(睁眼和言语)及总分、CRS-R单项评分(听觉、视觉、言语、交流和唤醒)及总分和FOUR单项评分(眼部和脑干)及总分优于对照组(均P<0.05),但2组患者的GCS单项评分(运动)、CRS-R单项评分(运动)和FOUR单项评分(运动和呼吸)评分比较不明显(均P>0.05)。2组患者均未发生不良事件。治疗组总有效率(79.41%)显著高于对照组(61.76%)(P<0.05)。结论 taVNS治疗pDoC有一定的疗效,可改善患者意识障碍程度,且安全可靠。
Objective To observe the clinical effect of transcutaneous auricular vagus nerve stimulation(taVNS)in the treatment of prolonged disorders of consciousness(pDoC).Methods A total of 68 patients with pDoC admitted to the Third Hospital of Baoji were enrolled between June 2020 and December 2022.Through randomized controlled trial,the patients were divided into control group(n=34)and treatment group(n=34).The control group received conventional treatment,and the treatment group received ta VNS treatment on the basis of the control group,both groups were treated for 4 weeks.The scores of Glasgow coma scale(GCS),coma recovery scale-revised(CRS-R),full outline of unresponsiveness(FOUR),safety and clinical efficacy were compared between the two groups.Results After treatment,the GCS single score(eye opening,verbal response and motor response)and total score,the CRS-R single score(auditory function scale,visual function scale,motor function scale,verbal function scale,communication scale and arousal scale)and total score and the FOUR single(eye response score,motor response score,brainstem reflexes score and respiration score)and total score in the two groups of patients were all increased(all P<0.05),and the GCS single score(eye opening and verbal response)and total score,the CRS-R single score(auditory function scale,visual function scale,verbal function scale,communication scale and arousal scale)and total score and the FOUR single(eye response score and brainstem reflexes score)and total score of the treatment group were better than those of the control group(all P<0.05),but the GCS single score(motor response),the CRS-R single score(motor function scale)and the FOUR single score(motor response score and respiration score)were not significantly different between the two groups(all P>0.05).No adverse events occurred in the two groups.The total effective rate in the treatment group(79.41%)was significantly higher than that in the control group(61.76%)(P<0.05).Conclusion ta VNS has a certain curative effect in the treatm
作者
雷彪
王晓峰
杨若琳
于蓬勃
李加龙
邵威
乔育
LEI Biao;WANG Xiaofeng;YANG Ruolin;YU Pengbo;LI Jialong;SHAO Wei;QIAO Yu(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Baoji Hospital of Chinese Medicine,Baoji 721001,China;The Third Hospital of Baoji,Baoji 721004,China)
出处
《中国实用神经疾病杂志》
2024年第5期552-556,共5页
Chinese Journal of Practical Nervous Diseases
基金
宝鸡市卫生健康委员会科研课题(编号:2019-69)。
关键词
经皮耳甲
迷走神经刺激
慢性意识障碍
重型颅脑损伤
Transcutaneous auricular
Vagus nerve stimulation
Prolonged disorders of consciousness
Heavy cranial brain injury
