摘要
目的探讨血清硒蛋白P与类风湿关节炎(RA)的相关性。方法选取RA病人96例为研究对象(RA组),根据疾病活动度评分分为稳定期49例,活动期47例;选取同期健康查体者50例为对照组。采用ELISA法检测两组血清硒蛋白P浓度。结果RA组与对照组血清硒蛋白P浓度差异有统计学意义(t=-7.169,P<0.001);RA稳定组与活动组血清硒蛋白P浓度差异有统计学意义(t=-4.964,P<0.001),C反应蛋白(CRP)、红细胞沉降率(ESR)差异也均有统计学意义(Z=-4.796、-4.194,P<0.05)。二分类Logistic回归分析显示,高硒蛋白P、高CRP的RA病人疾病活动度增高的风险增加(OR=1.286~1.368,P<0.05)。结论血清硒蛋白P是RA病人疾病活动的独立危险因素。
Objective To investigate the association between serum selenoprotein P and rheumatoid arthritis(RA).[WTHX]MethodsA total of 96 patients with RA were enrolled as subjects(RA group),and according to the disease activity score,they were divided into stable RA group with 49 patients and active RA group with 47 patients;50 individuals who underwent physical examination during the same period of time were enrolled as control group.ELISA was used to measure the concentration of serum selenoprotein P.Results There was a significant difference in the concentration of serum selenoprotein P between the RA group and the control group(t=-7.169,P<0.001),and there were significant differences between the stable RA group and the active RA group in the concentration of serum selenoprotein P(t=-4.964,P<0.001),C-reactive protein(CRP)(t=-4.796,P<0.05),and erythrocyte sedimentation rate(t=-4.194,P<0.05).The binary Logistic regression analysis showed that RA patients with high levels of selenoprotein P and CRP had an increased risk of the increase indisease activity(OR=1.286-1.368,P<0.05).[WTHX]ConclusionSerum selenoprotein P is an independent risk factor for disease activity in patients with RA.
作者
周雪梅
吴颖慧
温大蔚
辛苗苗
梁宏达
ZHOU Xuemei;WU Yinghui;WEN Dawei;XIN Miaomiao;LIANG Hongda(Department of Rheumatology and Immunology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)
出处
《青岛大学学报（医学版）》
CAS
2024年第2期271-273,共3页
Journal of Qingdao University(Medical Sciences)
基金
青岛大学附属医院科研资助项目(3395)。
关键词
关节炎
类风湿
硒蛋白P
免疫
预后
arthritis,rheumatoid
selenoprotein P
immunity
prognosis
