摘要
目的探讨布地奈德福莫特罗吸入剂对支气管哮喘患儿疾病控制水平的影响因素。方法回顾性分析宿迁市第一人民医院2019年1月至2022年1月收治的80例支气管哮喘患儿的临床资料。所有患儿均给予布地奈德福莫特罗吸入剂进行治疗,治疗12周后,通过儿童哮喘控制测试问卷对患儿疾病控制水平进行评估,根据得分分为完全控制组(>25分,33例)、部分控制组(22~25分,35例)及未控制组(<22分,12例)。比较3组患儿性别、年龄、体重指数、过敏原皮肤点刺试验阳性比例、病情严重程度、过敏体质、家属受教育程度、家族哮喘史和第1秒用力呼气容积占预计值百分比(FEV1%pred),采用多因素Logistic回归分析布地奈德福莫特罗吸入剂对疾病未控制的独立危险因素。结果单因素分析发现,3组在病情严重程度、过敏体质、FEV1%pred方面比较差异有统计学意义(P<0.05)。多因素Logistic回归分析发现,病情中重度、过敏体质、FEV1%pred≤82.695%是应用布地奈德福莫特罗吸入剂的支气管哮喘患儿疾病未控制的独立危险因素(P<0.05)。结论病情中重度、过敏体质、FEV1%pred≤82.695%是应用布地奈德福莫特罗吸入剂的支气管哮喘患儿疾病未控制的独立危险因素,临床需针对不同情况给予不同干预,以提高支气管哮喘患儿的疾病控制水平。
Objective To explore influencing factors for disease control in children with bronchial asthma treated by budesonide formoterol inhalant.Methods Clinical data of 80 children with bronchial asthma admitted to Suqian First Hospital from January 2019 to January 2022 were retrospectively analyzed.All the children were treated with budesonide formoterol inhalant.The disease control level was evaluated by the childhood asthma control test questionnaire after 12‑week treatment.According to the scores,the children were divided into complete control group(>25,33 cases),partial control group(22‑25,35 cases)and uncontrolled group(<22,12 cases).The gender,age,body mass index(BMI),positive result of allergen skin prick test(SPT),severity of illness,allergic constitution,educational level of the family,family history of asthma,and the percentage of forced expiratory volume in one second in estimated value(FEV1%pred)were compared among groups.Multivariate Logistic regression analysis was used to identify independent risk factors for poor disease control in children with bronchial asthma treated by budesonide formoterol inhalant.Results There were significant differences among the three groups in the severity of illness,allergic constitution,and FEV1%pred(P<0.05).Multivariate Logistic regression analysis confirmed that moderate to severe disease severity,allergic constitution and FEV1%pred≤82.695%were independent risk factors for poor disease control in children with bronchial asthma treated by budesonide formoterol inhalant.(P<0.05).Conclusion Moderate to severe disease severity,allergic constitution and FEV1%pred≤82.695%are risk factors for poor disease control in children with bronchial asthma treated by budesonide formoterol inhalant.Different interventions should be given according to different conditions so as to improve disease control in children with bronchial asthma.
作者
刘玲
童德银
沈勤
钱巧
Liu Ling;Tong Deyin;Shen Qin;Qian Qiao(Department of Pharmacy,Suqian First Hospital,Suqian 223800,China)
出处
《海军医学杂志》
2024年第4期413-416,共4页
Journal of Navy Medicine
基金
江苏省药学会天晴医院药学基金(Q202044)。
