摘要
目的:探讨肺部感染新生儿使用头孢类药物与哌拉西林的治疗效果。方法:选取2021年5月~2022年12月期间本院新生儿科收治86例新生儿肺部感染患儿作为研究对象。使用数字表格法将患儿分为I组(28例)、II组(28例)和III组(30例)。I组使用哌拉西林治疗,II组使用头孢类药物治疗,III组采用联合用药治疗。另纳入30例健康新生儿设为对照组。观察各组疗效、不良反应、益生菌菌群平衡情况。结果:III组治愈率最高为96.67%、其次I组治愈率为92.86%、II组治愈率为89.29%,但三组数据统计学分析,差异无统计学意义(P>0.05)。III组不良反应发生率显著高于I组、II组(P<0.05)。I组发生率为0%,显著低于III组的26.67%(χ^(2)=6.563,P<0.05);II组不良反应发生率为3.57%,显著低于III组的26.67%(χ^(2)=4.262,P<0.05);I组不良反与II组比较无显著差异(P>0.05)。以对照组健康新生儿作为参照,对照组类杆菌、双歧杆菌、乳酸菌等益生菌肠道菌群数均明显高于I组、II组、III组(P<0.05)。而I组与II组类杆菌、双歧杆菌、乳酸菌等益生菌肠道菌群数均明显高于III组(P<0.05),I组类杆菌、双歧杆菌、乳酸菌等益生菌肠道菌群数均明显高于II组(P<0.05)。结论:在肺部感染新生儿治疗中,联合哌拉西林、头孢类药物疗效与单一用药类似,但联合用药会增加肠道不良反应情况,且对肠道益生菌菌落平衡破坏较为严重;而单一用药以哌拉西林对肠道益生菌菌落数平衡影响最轻。
Objective:To investigate the therapeutic effect of cephalosporin and piperacillin in the treatment of neonates with pulmonary infection.Methods:From May 2021 to December 2022,86 neonates with pulmonary infection were selected as the study objects.The children were divided into group I(28 cases),Group II(28 cases)and group III(30 cases)using digital table method.Group I was treated with piperacillin,group II with cephalosporin,and group III with combination therapy.Another 30 healthy neonates were included as control group.The therapeutic effect,adverse reactions and the balance of probiotics in each group were observed.Results:The highest cure rate was 96.67%in group III,followed by 92.86%in group I and 89.29%in group II,but there was no statistical significance in the three groups(P>0.05).The incidence of adverse reactions in group III was significantly higher than that in groups I and II(P<0.05).The incidence in group I was 0%,which was significantly lower than that in group III(26.67%)(χ^(2)=6.563,P<0.05).The incidence of adverse reactions in group II(3.57%)was significantly lower than that in group III(26.67%)(χ^(2)=4.262,P<0.05).There was no significant difference between group I and group II(P>0.05).The number of intestinal flora of probiotics such as Bacillus,bifidobacterium and lactobacillus in control group was significantly higher than that in groups I,II and III(P<0.05).The intestinal flora numbers of probiotics such as bacillus,bifidobacterium and lactobacillus in groups I and II were significantly higher than those in group III(P<0.05),and the intestinal flora numbers of probiotics such as bacillus,bifidobacterium and lactobacillus in group I were significantly higher than those in group II(P<0.05).Conclusion:In the treatment of neonatal pulmonary infection,the efficacy of combined piperacillin and cephalosporin is similar to that of single drug,but combined drug can increase intestinal adverse reactions and seriously destroy the balance of intestinal probiotics.Piperacillin had the least effect on
作者
王先言
陈晓敏
张东梅
Wang Xian-yan;Chen Xiao-min;Zhang Dong-mei(Neonatal Intensive Care Unit,The First People's Hospital of Shangqiu,Shangqiu 476000,Henan,China)
出处
《四川生理科学杂志》
2024年第5期1068-1070,共3页
Sichuan Journal of Physiological Sciences
