摘要
目的观察宫颈高危型人乳头瘤病毒(HR-HPV)感染采用保妇康栓联合臭氧治疗的应用效果。方法选取2018年3月至2020年12月在南昌大学第四附属医院妇科检查中HPV检测为阳性的120例患者作为研究对象,根据随机数字表法分为试验组(60例)和对照组(60例)。对照组采用保妇康栓治疗,试验组采用保妇康栓联合臭氧治疗,两组共治疗3个疗程。比较两组患者的临床疗效、HPV转阴率、血清肿瘤坏死因子α(TNF-α)水平,白细胞介素-6(IL-6)水平、转化生长因子-β(TGF-β)水平和不良反应总发生率。结果试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05);试验组HR-HPV转阴率高于对照组,差异有统计学意义(P<0.05);试验组治疗后TNF-α、TGF-β水平低于对照组,IL-6水平高于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对宫颈HR-HPV患者采用保妇康栓联合臭氧治疗,效果确切,能够提高HPV转阴率,且安全性较高,值得临床推广应用。
Objective To observe the application effect of Baofukang Suppository combined with ozone treatment on high-risk human papilloma virus(HPV)infection in the cervix.Methods A total of 120 patients who were tested positive for HPV in gynecological examination in the Fourth Affiliated Hospital of Nanchang University from March 2018 to December 2020 were selected as research objects,and were divided into experimental group(60 cases)and control group(60 cases)according to random number table method.The control group was treated with Bafukang Suppository,the experimental group was treated with Bafukang Suppository combined with ozone therapy,and the two groups were treated for a total of 3 courses.The clinical efficacy,HPV negative conversion rate,serum tumor necrosis factorα(TNF-α)level,interleukin-6(IL-6)level,transforming growth factor-β(TGF-β)level and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P<0.05).The negative conversion rate of HR-HPV in experimental groups was higher than that in control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TNF-αand TGF-βin experimental groups were lower than those in control group,and the levels of IL-6 were higher than those in control group,with statistical significances(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of Baofukang Suppository combined with ozone therapy for high-risk cervical HPV patients has a definite effect,can improve the HPV conversion rate,and is relatively safe,which is worthy of clinical promotion and application.
作者
戴星
孙玉芳
胡鸣
焦榕芳
张凡
DAI Xing;SUN Yufang;HU Ming;JIAO Rongfang;ZHANG Fan(Department of Obstetrics and Gynecology,the Fourth Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang330000,China)
出处
《中国当代医药》
CAS
2024年第14期37-40,共4页
China Modern Medicine
基金
江西省卫生计生委中医药科研课题(2017A059)。
关键词
宫颈高危型
人乳头瘤病毒感染
臭氧
保妇康栓
Cervical high-risk type
Human papilloma virus infection
Ozone
Baofukang Suppository
