摘要
群体感应(quorum sensing, QS)是细菌利用信号分子进行种内或种间交流的一种通讯机制,借助该通讯机制微生物群体可以实现微生物个体无法完成的生理功能或行为调节,如生物膜形成、毒素分泌和生物发光等,以增强对外界胁迫环境的适应性。近期多组学研究发现,以自体诱导物-2(autoinducer-2, AI-2)为信号分子、LuxS为调节蛋白介导的LuxS/AI-2 QS是瘤胃微生物之间交流的主要通讯机制,影响着瘤胃微生物对饲料的利用效率。本文从AI-2的化学结构和转导途径对微生物LuxS/AI-2 QS进行总结,对LuxS/AI--2 QS在反刍动物瘤胃微生物定殖和饲料消化过程中的作用进行综述,并对LuxS/AI-2 QS在饲料消化、应激调控中的潜在作用进行展望,以期为通过LuxS/AI-2 QS调控瘤胃微生物消化代谢和稳态的生产策略提供理论参考。
Quorum sensing(QS)is a communication mechanism utilized by bacteria to facilitate intra-species or inter-species communication through the signaling molecules.Through this communication mechanism,microorganisms can collectively conduct physiological functions or regulate behaviors that cannot be achieved by microbial individual.These functions include biofilm formation,toxin secretion,bioluminescence,and other adaptive responses to enhance the adaptability of microorganisms against external stress environment.Recently,multi-omics studies have revealed that LuxS/AI-2 QS,mediated by the autoinducer-2(AI-2)signaling molecule and regulated by the LuxS protein,serves as the primary communication mechanism among rumen microbe,influencing their efficiency in feed utilization.This review provides a summary of the LuxS/AI-2 QS in rumen microbe,focusing on the chemical structure of AI-2 and its transduction pathways.The roles of LuxS/AI-2 QS in rumen microbial colonization and feed digestion in ruminants were reviewed,as well as the potential roles of LuxS/AI-2 QS in feed digestion and stress regulation.This review may provide a theoretical reference for production strategy by regulating the digestive metabolism and homeostasis of rumen microbe through LuxS/AI-2 QS.
作者
龙唐晖
周江汇
詹彦波
张健
赵向辉
李艳娇
欧阳克蕙
邱清华
LONG Tanghui;ZHOU Jianghui;ZHAN Yanbo;ZHANG Jian;ZHAO Xianghui;LI Yanjiao;OUYANG Kehui;QIU Qinghua(Jiangxi Province Engineering Research Center of Feed Development/Jiangxi Province Key Laboratory of Animal Nutrition/College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2024年第5期1893-1903,共11页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金项目(32260861,32160807)
江西省自然科学基金资助项目(20232BAB215051)
江西省主要学科学术和技术带头人培养计划“领军人才”项目(20213BCJL22043)
江西农业大学年轻科研创新团队项目(JXAUCXTD008)。
