摘要
小白菊内酯(parthenolide, PTL)是一种从小白菊中提取的倍半萜内酯,因其独特的化学性质和对多种肿瘤细胞的复合分子作用,被认为是一种极具潜力的抗癌候选药物。研究显示,PTL不仅能有效抑制核因子κB(nuclear factor kappa-light-chain-enhancer of activated B cells, NF-κB)和STAT-3等关键转录因子,还可以触发特定的细胞死亡路径,促使细胞内活性氧增加和Bcl-2家族蛋白改变。此外,PTL对癌症干细胞也显示出了特异性的靶向能力。鉴于PTL的显著功效,该化合物有希望成为一种新的靶向癌症治疗的药物。本篇综述聚焦于探讨PTL在肿瘤模型中的作用机制,特别是其对肿瘤细胞基因表达、信号转导以及不同细胞死亡类型的影响。
Parthenolide,a sesquiterpene lactone extracted from chamomile,is considered a highly potential anticancer candidate drug due to its unique chemical properties and complex molecular effects on various tumor cells.This review focuses on exploring the mechanisms of parthenolide in tumor models,particularly its impact on gene expression,signal transduction,and different types of cell death in tumor cells.The latest research findings reveal that parthenolide can not only effectively inhibit key transcription factors such as NF-κB and STAT-3 but also trigger specific cell death pathways leading to an increase in intracellular reactive oxygen species and changes in Bcl-2 family proteins.Moreover,parthenolide has shown specific targeting capabilities against cancer stem cells.Given the significant efficacy of parthenolide,this compound is promised to be a new drug targeting cancer therapy.
作者
徐博涛
柴杰
王永胜
XU Botao;CHAI Jie;WANG Yongsheng(Department of Gastric Surgery,The Affiliated Tumor Hospital,Shandong First Medical University,Jinan 250117,China;Department of Breast Surgery,The Affiliated Tumor Hospital,Shandong First Medical University,Jinan 250117,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
CAS
2024年第6期378-384,共7页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
山东省自然科学基金(ZR2021MH108)。
关键词
小白菊内酯
癌症治疗
化疗
凋亡
细胞死亡
氧化应激
parthenolide
cancer therapy
chemotherapy
apoptosis
cell death
oxidative stress
