摘要
骨质疏松症(osteoporosis, OP)是一种中老年人易患的骨代谢性疾病,以骨密度减低和骨微结构破坏为特征,伴随着大量的骨丢失,极易导致身体各部位发生脆性骨折,造成沉重的家庭及社会负担。因此,对OP基础理论研究及新药物开发具有重要的意义。随着OP分子机制研究的不断深入,相关调控因子陆续被发现,p53蛋白是细胞内重要的调控因子,调节着机体内各种细胞的增殖、分化、凋亡、自噬等多个生命过程。越来越多的证据表明,p53的表达量高低对骨的功能及代谢有着重要的调节作用,或将成为治疗OP等骨代谢疾病的新靶点。
Osteoporosis(OP) is a kind of bone metabolic disease usually happened in middle-aged and elderly, characterized by the reduction of bone mineral density and the destruction of bone microstructure. Accompanied by a large number of bone loss, it is easy to lead to fragility fractures in various parts of the body, causing heavy family and social burden. Therefore, it is of great significance to study the basic theory of OP and develop new drugs. With the deepening of research on the molecular mechanism of OP, relevant regulatory factors have been discovered one after another. p53 protein is an important intracellular regulatory factor, regulating the proliferation, differentiation, apoptosis, autophagy and other life processes of various cells in the body. The evidence is growing that p53 plays an important role in regulating the function and metabolism of bone and may become a new target for the treatment of bone metabolic diseases including OP.
作者
朱高明
郭艳波
张加豪
李刚
ZHU Gao-ming;GUO Yan-bo;ZHANG Jia-hao;LI Gang(The First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan 250011,China)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2024年第8期738-743,共6页
Orthopedic Journal of China
基金
山东省科技攻关计划项目(编号:2021CXGC010501)
山东省自然科学基金项目(编号:ZR2020KH012)。
