摘要
卵巢早衰是一种严重影响育龄妇女生理、生育、心理健康的内分泌疾病,目前尚无有效的恢复卵巢功能的治疗手段。卵巢颗粒细胞在研究保护卵巢功能方面发挥重要作用,颗粒细胞是卵巢的基础功能单位,其增殖、分化、凋亡直接影响着卵母细胞的发育以及卵泡的成熟。近年来很多研究表明,间充质干细胞(MSC)及其外泌体通过促进颗粒细胞增殖、抑制凋亡、调节氧化应激等途径促进卵泡发育,恢复卵巢早衰患者的卵巢功能及生育能力。本文总结并分析近年来关于MSC及其外泌体调控卵巢颗粒细胞,恢复卵巢功能的研究进展,深入探究其存在的相关治疗机制,评估其应用于临床治疗的潜力,为MSC治疗卵巢早衰的进一步研究及临床应用提供理论依据。
Premature ovarian failure(POF)is an endocrine disease that seriously affects the physical,reproductive and mental health of women of childbearing age.At present,there is no effective treatment to restore ovarian function.Ovarian granulosa cells play an important role in protecting ovarian function.Granulosa cells(GCs)are the basic functional units of ovary,and their proliferation,differentiation and apoptosis directly affect the development of oocytes and follicular maturation.In recent years,many studies have shown that mesenchymal stem cells(MSC)and their exosomes(MSC-Exo)promote follicular development and restore ovarian function and fertility in patients with POF by promoting the proliferation of GCs,inhibiting apoptosis,and regulating oxidative stress.In this paper,we summarize and analyze the research progress of MSC and MSC-Exo in regulating ovarian GCs and restoring ovarian function in recent years,deeply explore their related therapeutic mechanisms,evaluate their potential for clinical treatment,and provide a theoretical basis for the further research and clinical application of mesenchymal stem cells in the treatment of POF.
作者
刘维宏
邵娜
于艺
LIU Weihong;SHAO Na;YU Yi(Jimo District People’s Hospital of Qingdao City,Qingdao,Shandong 266200,China;Affiliated Hospital of Shandong University of TCM,Ji’nan,Shandong 250000,China)
出处
《中国优生与遗传杂志》
2024年第3期659-665,共7页
Chinese Journal of Birth Health & Heredity
基金
山东省中医药科技青年项目(2020Q013)。
关键词
卵巢早衰
颗粒细胞
间充质干细胞
外泌体
premature ovarian failure
granulosa cells
mesenchymal stem cells
exosomes
