摘要
小细胞肺癌脑转移是一个治疗难题,传统治疗方式存在局限性。免疫治疗与化疗、放疗及靶向药物联合治疗为小细胞肺癌脑转移患者提供了一种新的选择。化疗联合免疫治疗逐渐成为广泛期小细胞肺癌的一线治疗,其对脑转移亚组的疗效也得到一定证实。脑部放射治疗联合免疫治疗是一种思路,尽管指南未明确提及联合方式,但从分子机制及小样本研究来看,其组合方式倾向于推荐同步治疗。抗血管生成药物联合免疫治疗疗效优于单药,不良反应也在可接受范围内。全文主要阐述免疫疗法治疗小细胞肺癌脑转移的最新进展,并进一步探讨其与化疗、放疗以及靶向药物联合治疗所带来的疗效及相关不良反应。
Brain metastasis of small cell lung cancer is a challenge for conventional therapies.However,the combination of immunotherapy with chemotherapy,radiotherapy and targeted therapy provides a new option for small cell lung cancer patients with brain metastases.Chemotherapy combined with immunotherapy has been a first-line treatment for extensive small cell lung cancer,and its efficacy for brain metastasis patients has been also confirmed.Brain radiation therapy combined with immunotherapy is a new approach,although not explicitly mentioned in clinical guidelines.Based on the molecular mechanism and results of small-sample studies,the combination approach tends to be recommended as a synchronous therapy.The efficacy of anti-angiogenic drugs combined with immunotherapy is better than that of single drug,and the adverse reactions are also within the acceptable range.This paper reviews the recent progress on immunotherapy in the treatment of brain metastases of small cell lung cancer,and further discusses the efficacy and related side effects of immunotherapy combined with chemotherapy,radiotherapy and targeted therapy.
作者
阙述浩
封巍
徐裕金
QUE Shuhao;FENG Wei;XU Yujin(Zhejiang Chinese Medical University,Hangzhou 310053,China;Zhejiang Cancer Hospital,Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou 310022,China)
出处
《肿瘤学杂志》
CAS
2024年第3期177-185,共9页
Journal of Chinese Oncology
基金
2021年浙江省卫生健康新技术产品研发项目(2021PY038)。
关键词
小细胞肺癌
中枢神经系统转移
免疫疗法
联合治疗
不良反应
small cell lung cancer
central nervous system metastasis
immunotherapy
combination therapy
adverse reactions
