摘要
目的:观察他克莫司(TAC)治疗老年溃疡性结肠炎(UC)的临床效果。方法:回顾性分析2019年6月—2023年9月在南通大学附属医院就诊的80例老年UC患者的临床资料,按照治疗方法不同分为对照组(n=40)和试验组(n=40)。对照组予以传统5-氨基水杨酸类药物进行治疗,试验组予以他克莫司胶囊进行治疗,两组均治疗12周,比较两组患者治疗前后的炎症因子水平、Mayo疾病活动指数,治疗期间药物不良反应发生情况。结果:治疗后,两组患者白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗12周后,两组患者Mayo疾病活动指数低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。试验组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论:TAC是治疗老年性UC患者的有效药物,可显著减轻患者炎症,促进肠黏膜修复,且不良反应发生率较低。
Objective To observe the clinical efficacy of tacrolimus(TAC)in the treatment of elderly patients with ulcerative colitis(UC).Methods Retrospective analysis of clinical data of 80 elderly patients with UC who visited the Affiliated Hospital of Nantong University from June 2019 to September 2023.They were divided into a control group(n=40)and an experimental group(n=40)according to different treatment methods.The control group was treated with traditional 5-aminosalicylic acid drugs,while the experimental group was treated with tacrolimus capsules.Both groups were treated for 12 weeks,and the levels of inflammatory factors,Mayo disease activity index,and incidence of adverse drug reactions during treatment were compared between the two groups before and after treatment.Results After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in two groups were lower than before treatment,and the experimental group was lower than the control group,the difference was statistically significant(P<0.05).After 12 weeks of treatment,the Mayo disease activity index of the two groups of patients was lower than before treatment,and the experimental group was lower than the control group,with a statistically significant difference(P<0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions TAC is an effective drug for treating elderly UC patients,which can significantly reduce inflammation,promote intestinal mucosal repair,and have a lower incidence of adverse reactions.
作者
钱奕羽
QIAN Yiyu(Department of Clinical Medicine,Medical College of Nantong University,Nantong,Jiangsu 226006,China)
出处
《医药前沿》
2024年第15期32-34,38,共4页
Journal of Frontiers of Medicine
关键词
溃疡性结肠炎
老年
他克莫司
治疗效果
Ulcerative colitis
Elderly patients
Tacrolimus
Treatment effect
