摘要
目的分析焦作地区妊娠晚期生殖道B族溶血性链球菌(GBS)感染的流行情况和产妇的妊娠结局。方法选取2021年3月至2023年4月焦作地区三所医院妊娠晚期产检产妇487例,采集其肛周或阴道分泌物予以GBS培养,且经B超核对检查,按孕妇是否发生GBS感染分为感染组、未感染组,对比其凝血功能及妊娠结局情况,将感染组按抗感染情况分为充分组(充分产时抗生素预防)、不充分组(不充分产时抗生素预防)、未治疗组,对比其妊娠结局。结果487例产妇中47例存在GBS感染,感染率为9.65%(47/487);感染组活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)较未感染组缩短,纤维蛋白原(FIB)高于未感染组(P<0.05);感染组的产褥感染、新生儿肺炎、低出生体重儿发生率(6.38%、8.51%、14.89%)均较未感染组(1.14%、2.05%、3.86%)更高(P<0.05);充分组的胎儿窘迫、低出生体重儿等发生率均低于未治疗组(P<0.05),未治疗组的胎膜早破发生率高于不充分组(P<0.05)。结论焦作地区妊娠晚期孕妇生殖道GBS感染率高,且对孕妇凝血功能及妊娠结局、新生儿均有不良影响,经充分的抗生素抗感染治疗可起到一定程度的预防作用。
Objective To analyze the prevalence of genital tract group B streptococcus(GBS)infection in late pregnancy in Jiaozuo and the pregnancy outcomes.Methods A total of 487 pregnant women in late pregnancy who received prenatal examination at three hospitals in Jiaozuo from March 2021 to April 2023 were selected.Their perianal or vaginal secretions were collected for GBS culture.Then,the pregnant women were divided into infected group and uninfected group according to whether they had GBS infection.Coagulation function and pregnancy outcomes of the two groups were compared.Women in the infected group were divided into sufficient treatment group(sufficient antibiotic prevention during childbirth),insufficient treatment group(insufficient antibiotic prevention during childbirth),and untreated group.Pregnancy outcomes of these groups were comparatively analyzed.Results Of the 487 pregnant women,47 had GBS infection,with an infection rate of 9.65%(47/487).Activated partial thromboplastin time(APTT)and plasma prothrombin time(PT)of the infected group were shorter than those of the uninfected group,and fibrinogen(FIB)level was higher than that of the uninfected group(P<0.05).The incidence rates of puerperal infection,neonatal pneumonia and low birth weight infants in the infected group(6.38%,8.51% and 14.89%)were higher than those in the uninfected group(1.14%,2.05% and 3.86%)(P<0.05).The incidence rates of fetal distress and low birth weight infants in the sufficient treatment group were lower than those in the untreated group(P<0.05).The incidence of premature rupture of membranes in the untreated group was higher than that in the insufficient treatment group(P<0.05).Conclusion The genital tract GBS infection rate in late pregnancy in Jiaozuo is high,and it has adverse effect on maternal coagulation function and pregnancy outcomes as well as neonates.Sufficient antibiotic anti-infection treatment is helpful for prevention.
作者
杨晓杰
宋俊霞
张丽丽
YANG Xiao-jie;SONG Jun-xia;ZHANG Li-li(Department of Obstetrics and Gynecology,Jiaozuo Maternal and Child Health Hospital,Jiaozuo,Henan 454000,China;Department of Obstetrics and Gynecology,Central Hospital of Jiaozuo Coking Coal Industry Group,Jiaozuo,Henan 454000,China;Department of Obstetrics and Gynecology,Jiaozuo People's Hospital,Jiaozuo,Henan 454000,China)
出处
《医药论坛杂志》
2024年第8期864-868,共5页
Journal of Medical Forum
关键词
焦作地区
妊娠晚期
生殖道
B族溶血性链球菌
妊娠结局
Jiaozuo
Late pregnancy
Genital tract
Group B streptococcus
Prevalence
Pregnancy outcome
