摘要
目的:分析福多司坦联合布地奈德治疗慢性阻塞性肺疾病的临床效果。方法:选取2021年1月—2022年1月昆山宗仁卿纪念医院收治的80例慢性阻塞性肺疾病患者作为研究对象,利用随机数字表法分为两组,各40例。参照组使用布地奈德治疗,试验组在参照组基础上使用福多司坦治疗。比较两组临床疗效。结果:治疗后,两组用力肺活量、第1秒用力呼气容积高于治疗前,且试验组高于参照组,两组慢性阻塞性肺疾病评估测试评分低于治疗前,且试验组低于参照组,差异有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α、白细胞介素-8和白细胞介素-10水平低于治疗前,且试验组低于参照组,差异有统计学意义(P<0.05)。治疗后,两组最大呼气中期流速、25%肺活量时最大呼气流量、50%肺活量时最大呼气流量大于治疗前,且试验组大于参照组,差异有统计学意义(P<0.05)。治疗后,两组血清丙二醛水平低于治疗前,且试验组低于参照组,两组超氧化物歧化酶水平高于治疗前,且试验组高于参照组,差异有统计学意义(P<0.05)。结论:福多司坦联合布地奈德治疗慢性阻塞性肺疾病的临床效果较好,可提高患者肺功能、小气道功能,改善临床症状、炎性反应、氧化应激情况。
Objective:To analyze the clinical effect of fudosteine combined with budesonide in the treatment of chronic obstructive pulmonary disease.Methods:A total of 80 patients with chronic obstructive pulmonary disease who received treatment in Jen Ching Memorial Hospital from January 2021 to January 2022 were selected as the study subjects.They were divided into two groups using a random number table method,with 40 cases in each group.The reference group was treated with budesonide and the experimental group was treated with fudosteine on the basis of the reference group.The clinical efficacy in two groups was compared.Results:After treatment,the forced vital capacity and forced expiratory volume in 1 second in the two groups were higher than those before treatment,and these indexes in the experimental group were higher than those in the reference group,while the scores of the chronic obstructive pulmonary disease assessment test in the two groups were lower than those before treatment,and the scores in the experimental group were lower than those in the reference group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-8 and interleukin-10 in the two groups were lower than those before treatment,and the levels in the experimental group were lower than those in the reference group,with a statistically significant difference(P<0.05).After treatment,the maximum mid-expiratory flow rate,maximum expiratory flow at 25%vital capacity,and maximum expiratory flow at 50%vital capacity in two groups were higher than those before treatment,and these indexes in the experimental group were higher than those in the reference group,with a statistically significant difference(P<0.05).After treatment,the serum malondialdehyde level in the two groups was lower than that before treatment,and the level in the experimental group was lower than that in the reference group,while the level of superoxide dismutase in the two groups was higher than that before treatment,an
作者
陈旭明
Chen Xuming(Jen Ching Memorial Hospital,Kunshan 215300,Jiangsu Province,China)
出处
《中国社区医师》
2024年第10期20-22,共3页
Chinese Community Doctors
关键词
布地奈德
慢性阻塞性肺疾病
福多司坦
肺功能
Budesonide
Chronic obstructive pulmonary disease
Fudosteine
Pulmonary function
