摘要
To the Editor,Anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV)is an autoimmune condition that mainly affects small vessels of the body.AAV is a condition that may have multisystem manifestations and has an increased prevalence among older individuals.1 AAV patients conventionally present with symptoms at 65 years of age or older.Previous studies have demonstrated worse clinical outcomes in the aging population.Many older patients live with various comorbidities in addition to potentially relapsing AAV.Dealing with the pathophysiological impact of AAV can be burdensome,as this multifaceted condition may lead to impairment of physical function and contribute to significant mental and emotional stress.The impact of aging on the pathophysiology of AAV is not fully known.Immune dysregulation induced by cell senescence is hypothesized to be a key factor,alongside a mixture of genetic and environmental factors2.
