摘要
青少年精神分裂症(adolescent-onset schizophrenia,AOS)属于早发性精神分裂症的范畴,是指发病年龄在13~18岁之间的精神分裂症,与成人发病的精神分裂症相比,其症状更不典型,程度更严重,对抗精神病药物的治疗反应更差,并且其病因及发病机制至今尚不明确。静息态功能MRI(resting-state functional MRI,rs-fMRI)是一种操作便捷、无创客观且受试者易于配合的MRI技术,它能够从局部和整体反映脑神经元的自发性活动情况,为AOS神经病理学机制研究提供了强有力的手段。本文从功能分离分析和功能整合分析两方面展开,围绕rs-fMRI在AOS研究中应用的最新进展进行综述,探讨了当前研究的不足之处,并对未来进一步研究的方向进行了展望,旨在为进一步探索精神分裂症的病理生理学机制提供一定线索和依据。
Adolescent-onset schizophrenia belongs to the category of early-onset schizophrenia,which refers to schizophrenia with onset between the ages of 13-18 years old.Compared with adult-onset schizophrenia,its symptoms are more atypical and severe,its response to antipsychotic medications is poorer,and its etiology and pathogenesis are not yet clear.Resting-state functional MRI(rs-fMRI)is a convenient,noninvasive and objective MRI technique that is easy for subjects to cooperate with,and it can reflect the spontaneous activity of brain neurons both locally and holistically,providing a powerful means for the study of the neuropathological mechanisms of AOS.In this paper,we review the latest progress in the application of rs-fMRI in the study of AOS from the aspects of functional segregation analysis and functional integration analysis,discuss the shortcomings of the current study,and look forward to the direction of further research in the future,with the aim of providing certain clues and bases for further exploring the pathophysiological mechanisms of schizophrenia.
作者
王露
刘芮杉
廖娟
李宏伟
卓丽华
WANG Lu;LIU Ruishan;LIAO Juan;LI Hongwei*;ZHUO Lihua*(Medical Imaging College,North Sichuan Medical College,Nanchong 637000,China;Department of Radiology,the Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang 621000,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第5期168-174,180,共8页
Chinese Journal of Magnetic Resonance Imaging
基金
国家重点研发计划项目(编号:2022YFC2009901-05,2022YFC2009900)。
关键词
精神分裂症
青少年
磁共振成像
静息态功能磁共振成像
schizophrenia
adolescent
magnetic resonance imaging
resting-state functional magnetic resonance imaging
