摘要
目的采用基于梯度的方法分析阿尔茨海默病(Alzheimer’s disease,AD)大脑皮层组织沿脑-小脑连接梯度的功能层级结构及其与小脑相互作用的改变,以及与认知功能障碍之间的联系。材料与方法基于AD神经影像学计划(Alzheimer’s Disease Neuroimaging Initiative,ADNI)公开数据库,共纳入33名AD患者和46名年龄、性别相匹配的健康对照(healthy controls,HC)。采用梯度计算方法,通过对所有被试的脑-小脑静息态功能连接矩阵进行非线性分解,得到了每个被试的脑-小脑功能连接梯度。采用双样本t检验进行组间的脑-小脑梯度分数差异分析,以及梯度异常的脑区与小脑功能连接的组间比较,并采用相关分析评估了异常的梯度分数以及功能连接值与临床量表分数的相关性。结果与HC组相比,AD组在涉及高级认知功能区域右侧颞下回(right inferior temporal gyrus,RITG)(t=4.71,P<0.001)的梯度分数发生局部性改变,进一步基于梯度异常脑区为种子点的功能连接分析显示出RITG到小脑双侧CrusⅡ区域以及延伸到的ⅦB区(右侧:t=-4.89,P<0.001,左侧:t=-4.98,P<0.001)功能连接的降低。临床量表相关性分析显示,AD患者的梯度异常脑区的连接梯度分数与社会活动功能(Functional Activity Questionnaire,FAQ)评分密切相关(r=0.40,P=0.025)。结论AD患者参与高级认知功能的局部区域功能层级结构的异常变化及其与小脑双侧CrusⅡ和ⅦB脑区的功能连接降低可能是认知功能受损的潜在因素之一。
Objective:To analyze the functional hierarchy of Alzheimer's disease(AD)cerebral cortex along the brain-cerebellar connectivity gradient and its altered interaction with the cerebellum and the association with cognitive dysfunction using a gradient-based approach.Materials and Methods:A total of 33 AD patients and 46 age,sex matched healthy controls(HC)were included based on the publicly available database ANDI.The cerebral-cerebellar functional connectivity gradient of each subject was obtained by nonlinearly decomposing the cerebral-cerebellar resting-state functional connectivity matrix of all subjects,using gradient computation method.Two-sample t-tests were performed to analyze differences of cerebral-cerebellar gradient scores between groups,as well as group's comparisons of functional connectivity between abnormal regions of gradients and cerebellar,and correlation analyses were used to assess the correlation of abnormal gradient scores and connectivity values with scores on clinical scales.Results:Compared with healthy controls,AD patients had locally altered gradient scores in the right inferior temporal gyrus(RITG)(t=4.71,P<0.001)which involved in higher cognitive functions,and further functional connectivity analyses based on the gradient-abnormal cerebral region as a seed point showed functional connectivity of RITG to the bilateral CrusⅡregion and extending to theⅦB region of the cerebellum(right:t=−4.89,P<0.001;left:t=−4.98,P<0.001)was reduced.Clinical scale correlation analyses showed that connectivity gradient scores in gradient-abnormal brain regions were strongly correlated with Functional Activity Questionnaire(FAQ)scores(r=0.40,P=0.025)in AD patients.Conclusions:The abnormal changes in the functional hierarchy of locoregional areas involved in higher cognitive function in AD patients and their reduced functional connectivity with bilateral cerebellar CrusⅡandⅦB regions may be one of the potential factors for cognitive impairment.
作者
何美荣
莫贤
游晚芳
孙昂
张俊然
HE Meirong;MO Xian;YOU Wanfang;SUN Ang;ZHANG Junran(College of Electrical Engineering,Sichuan University,Chengdu 610065,China;College of Electrical Engineering,Northwest Minzu University,Lanzhou 730070,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第5期1-7,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:12126606)
四川省科技计划项目(编号:23ZDYF2913)
德阳科技(揭榜)项目(编号:2021JBJZ007)
四川大学“医学+信息”中心融合创新项目(编号:YGJC012)
琶洲实验室(黄浦)“数学与医疗健康交叉重点专项”(编号:2023K0605)
西北民族大学“中央高校基本业务费”项目(编号:31920230132)。
关键词
阿尔茨海默病
脑-小脑连接梯度
静息态功能连接
磁共振成像
功能层级结构
Alzheimer's disease
cerebral-cerebellar connection gradient
resting-state functional connectivity
magnetic resonance imaging
functional hierarchy
