摘要
目的 研究心型脂肪酸结合蛋白(H-FABP)、氨基端脑钠肽前体(NT-proBNP)对急性心力衰竭患者容量负荷状态及预后的评估。方法 本研究为前瞻性研究,以2021年1月至2022年1月于安阳市人民医院急诊住院的老年急性心力衰竭患者83例作为研究组,另选取83例健康者作为对照组。根据相对容量平衡水平,将以上83例患者分为容量超负荷组和非容量超负荷组,对所有出院患者随访3个月,将发生死亡的患者归为死亡组,其余为生存组。比较研究组与对照组不同容量负荷、不同预后的H-FABP、NT-proBNP水平之间的差异,研究H-FABP、NT-proBNP与生存状况以及容量负荷状态的相关性。结果 研究组患者的H-FABP、NT-proBNP水平高于对照组(P<0.001);容量超负荷组患者的H-FABP、NT-proBNP水平高于非容量超负荷组(P<0.05);死亡组患者的H-FABP、NT-proBNP水平高于生存组(P<0.05)。通过相关性分析,患者的死亡以及容量超负荷与H-FABP、NT-proBNP呈现正相关(P<0.001)。结论 H-FABP、NT-proBNP与急性心力衰竭患者容量负荷状态及预后呈现相关性,有助于评估急性心力衰竭的严重程度,对预后不良患者起到积极的指导治疗作用。
Objective To investigate the evaluation of heart type-fatty acid binding protein(H-FABP)and N-terminal pro-brain natriuretic peptide(NT-proBNP)on volume load status and prognosis in patients with acute heart failure.Methods This study was a prospective study that included 83 elderly patients with acute heart failure admitted to the emergency department of Anyang People’s Hospital from January 2021 to January 2022 as the research group.Another 83 individuals undergoing health examinations during the same period were selected as the control group.Based on relative volume balance levels,the 83 patients were divided into overloaded capacity group and non-overloaded capacity group.All discharged patients were followed up for three months,with those who died categorized as the death group and others as the survival group.The differences in H-FABP and NT-proBNP levels between the research group and control group,different volume loads groups along with different prognoses were compared to investigate their correlation with survival status and volume load state.Results The levels of H-FABP and NT-proBNP in the research group were significantly higher than those in the control group(P<0.001).The levels of H-FABP and NT-proBNP in overloaded capacity patients were significantly higher than those in non-overloaded capacity patients(P<0.05).The levels of H-FABP and NT-proBNP in deceased patients were significantly higher than those in surviving patients(P<0.05).Through correlation analysis,it was found that patient mortality is positively correlated with both overload capacity level along with H-FABP and NT-proBNP(P<0.001).Conclusion H-FABP and NT-proBNP are correlated with the volume load status and prognosis of patients with acute heart failure,which helps in evaluating the severity of acute heart failure and plays a positive role in guiding treatment for patients with poor prognosis.
作者
张晓丽
张海柱
可海霞
王永革
魏华
ZHANG Xiaoli;ZHANG Haizhu;KE Haixia;WANG Yongge;WEI Hua(Department of Emergency Medicine,Anyang People’s Hospital,Anyang 455000,China;Department of Cardiology,Anyang People’s Hospital,Anyang 455000,China;Teaching and Research Office of Surgery,Henan University of Nursing,Anyang 455000,China)
出处
《河南医学研究》
CAS
2024年第10期1834-1837,共4页
Henan Medical Research
基金
河南省医学科技攻关计划(联合共建)项目(LHGJ20191272)。
关键词
心型脂肪酸结合蛋白
容量负荷状态
急性心力衰竭
预后
氨基端脑钠肽前体
heart-type fatty acid-binding protein
volume load status
acute heart failure
prognosis
N-terminal pro-brain natriuretic peptide
