摘要
目的探究急性缺血性脑卒中(acute ischemic stroke,AIS)病人静脉溶栓治疗后出血转化与脑白质高信号(white matter hyperintensity,WMH)的相关性。方法回顾性分析137例AIS病例资料,均进行静脉溶栓治疗,根据是否发生出血转化分为出血组(53例)和未出血组(84例)。采用单因素与Logistic回归分析AIS病人治疗后出血转化的危险因素。结果两组病人年龄、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、高血压、发病到治疗时间、WMH程度比较,差异有统计学意义(P<0.05)。Logistic回归分析显示中重度WMH(OR=2.796,95%CI:1.450-5.391)是AIS病人治疗后出血转化的危险因素(P<0.05)。结论WMH是影响AIS病人溶栓治疗后出血转化的危险因素,中重度WMH病人发生出血转化的风险更高。
Objective To investigate the correlation between hemorrhagic transformation and white matter hyperintensity(WMH)in patients with acute ischemic stroke(AIS)after intravenous thrombolysis.Methods The clinical data of 137 patients with AIS were analyzed retrospectively,all of whom underwent intravenous thrombolysis therapy,and were divided into hemorrhagic transformation group(53 cases)and non-hemorrhagic transformation group(84 cases)according to whether hemorrhagic transformation occurred.Univariate and logistic regression analysis were performed to analyze the risk factors of hemorrhagic transformation in AIS patients after treatment.Results There were significant differences between the two groups in age,NIHSS score,hypertension,onset to treatment time,and WMH degree(P<0.05).Logistic analysis showed that moderate to severe WMH(OR=2.796,95%CI:1.450-5.391)was a risk factor for hemorrhagic transformation in patients with AIS after treatment(P<0.05).Conclusions WMH is a risk factor for hemorrhagic transformation after thrombolytic therapy in patients with AIS,and patients with moderate to severe WMH have a higher risk of hemorrhagic transformation.
作者
常虹
李雁翔
王琳
Chang Hong;Li Yanxiang;Wang Lin(Department of Cerebrology,Beichen Hospital,Tianjin 300400,China)
出处
《中国微侵袭神经外科杂志》
CAS
2024年第3期144-147,共4页
Chinese Journal of Minimally Invasive Neurosurgery
基金
天津市北辰区科技计划项目(编号:SHGY-2020005)。
关键词
脑卒中
缺血性
急性
静脉溶栓治疗
出血转化
脑白质高信号
stroke,ischemic,acute
intravenous thrombolysis treatment
bleeding transformation
white matter hyperintensity
