摘要
目的对比单纯抗凝与其联合介入方法治疗重症颅内静脉血栓形成(CVT)的效果。方法根据治疗方法将65例重症CVT患者纳入抗凝组(n=32)或联合组(n=33),比较组间入院、出院时改良Rankin量表(mRS)评分、患者预后、血管再通率,以及随访期间并发症发生率。结果组间入院时mRS评分差异无统计学意义(P>0.05);联合组出院时mRS评分低于抗凝组(P<0.05)。出院时(84.85%vs.59.38%)、出院后6个月(87.88%vs.65.63%)及12个月(93.94%vs.75.00%),联合组预后良好率均高于抗凝组(P均<0.05)。出院时联合组血管再通率高于抗凝组(100%vs.75.00%,P<0.05)。截至随访末,组间并发症发生率差异无统计学意义(15.15%vs.18.75%,P>0.05)。结论对于重症CVT患者,相比单纯抗凝,以抗凝联合介入方法进行治疗可明显减轻症状、改善预后。
Objective To compare therapeutic efficacy of anticoagulation alone and combining with intervention for treating severe cerebral venous thrombosis(CVT).Methods Data of 65 severe CVT patients were retrospectively analyzed.The patients were divided into anticoagulation group(n=32)or combined group(n=33)according to therapeutic methods.The modified Rankin scale(mRS)score at admission and discharge,the prognosis of patients,vascular recanalization rate as well as incidence of complications during follow-up period were compared between groups.Results No significant difference of mRS scores at admission was found between groups(P>0.05),while mRS scores of combined group were lower than of anticoagulation group at discharge(P<0.05).The rate of good prognosis at discharge(84.85%vs.59.38%),6 months after discharge(87.88%vs.65.63%)and 12 months after discharge(93.94%vs.75.00%)in combined group were all higher than those in anticoagulation group(all P<0.05).The vascular recanalization rate in combined group was higher than that in anticoagulant group(100%vs.75.00%,P<0.05).At the end of follow-up,no significant difference of complication incidence was found between groups(15.15%vs.18.75%,P>0.05).Conclusion For patients with severe CVT,anticoagulation combined with interventional therapy could significantly alleviate clinical symptoms and improve prognosis compared with anticoagulation alone.
作者
徐振
何浩
许莺歌
闫磊
张松
朱明
吴垠垠
水少锋
XU Zhen;HE Hao;XU Yingge;YAN Lei;ZHANG Song;ZHU Ming;WU Yinyin;SHUI Shaofeng(Department of Interventional Radiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国介入影像与治疗学》
北大核心
2024年第5期276-280,共5页
Chinese Journal of Interventional Imaging and Therapy
关键词
脑静脉
颅内血栓形成
溶栓疗法
血栓切除术
cerebral veins
intracranial thrombosis
thrombolytic therapy
thrombectomy
