摘要
白血病已成为人类健康的重要威胁,感染并发症是临床白血病顺利治疗的主要障碍。白血病本身肿瘤特点和高强度化学治疗导致肠道屏障完整性损伤,肠道菌群易位是血流感染(BSI)的重要原因。实验室证实的黏膜屏障损伤所致血流感染(MBI-LCBI)是急性白血病患者BSI的重要组成,但相关研究非常有限。本文通过文献分析,综述黏膜屏障损伤、细菌易位,以及MBI-LCBI定义、诊断、流行情况,分析肠道微生态调节黏膜屏障完整性及MBI-LCBI的作用机制,以期为化学治疗介导黏膜炎及MBI-LCBI的防治及管理提供理论基础。
Leukemia has become an important threat to human health,and infection complications are the main obstacle to the clinical leukemia treatment.The intestinal barrier integrity was damaged due to the tumor characte-ristics of leukemia and high-intensity chemotherapy,intestinal bacterial translocation is an important cause for bloodstream infection.Mucosal barrier injury laboratory-confirmed bloodstream infection(MBI-LCBI)is an important component of bloodstream infection in patients with acute leukemia,but relevant research is very limited.The paper reviews the mucosal barrier injury,bacterial translocation,as well as the definition,diagnosis and prevalence of MBI-LCBI,analyzes the mechanism of intestinal microecology in regulating intestinal mucosal barrier integrity and effect of MBI-LCBI,aiming to provide theoretical basis for prevention,treatment and management of chemotherapy-induced mucositis and MBI-LCBI.
作者
赵慧函
何雨
应燕萍
ZHAO Hui-han;HE Yu;YING Yan-ping(Department of Hematology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Laboratory Medicine,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Nursing,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;School of Information and Management,Guangxi Medical University,Nanning 530021,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2024年第5期646-651,共6页
Chinese Journal of Infection Control
基金
广西医疗卫生适宜技术开发与推广应用项目(S2023066)
广西医科大学第一附属医院护理临床研究攀登计划项目(YYZS2020031)
广西中青年教师基础能力提升项目(2023KY0128)。
关键词
白血病
血流感染
肠道屏障
细菌易位
leukemia
bloodstream infection
intestinal barrier
bacterial translocation
