摘要
抑郁症是一种具有复杂病因的慢性综合征,有近三分之一的患者对目前的抗抑郁药不敏感。为提高更多抑郁症患者的生活质量,研发新的抗抑郁药物势在必行。神经活性类固醇是类固醇激素的代谢物,研究发现其具有多种生物活性,可通过多途径、多靶点发挥抗抑郁作用。该文通过整理神经活性类固醇抗抑郁症的相关文献,为神经活性类固醇治疗抑郁症提供科学依据,也为抗抑郁药物的研发提供新思路。
Depression is a chronic syndrome with complex etiology.Nearly one-third of patients are not sensitive to current antidepressants.In order to ensure the quality of life of all patients with depression,it is essential to explore new antidepressant treatment methods.Neuroactive steroids are metabolites of steroid hormones play an antidepressant role through multiple pathways and multiple targets.In this paper,the literature on neuroactive steroids in the treatment of depression was summarized to provide scientific basis for neuroactive steroids in the treatment of depression,and to provide new ideas for the development of antidepressant drugs.
作者
张冉冉
吴志刚
ZHANG Ran-ran;WU Zhi-gang(College of Pharmacy,Hebei North University,Zhangjiakou Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Neurodegenerative Diseases,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China)
出处
《神经药理学报》
2024年第1期49-56,共8页
Acta Neuropharmacologica
基金
河北省省属高校基本科研业务费自然科学研究计划项目(No.JYT2021001)
河北北方学院校级科研项目(No.XJ2023034)
河北北方学院博士科研启动基金项目资助。
