摘要
目的:探讨冠心病(CHD)经皮冠状动脉介入术治疗前后患者血清肺炎衣原体抗体IgA(CP-IgA)、超敏C-反应蛋白(hs-CRP)及血管生成素-2(Ang-2)变化及预后预测价值。方法:选取CHD患者135例为观察组,根据患者预后情况分为预后良好组(119例)及预后不良组(16例)。另选取同期体检健康者135例为对照组。比较观察组和对照组、观察组PCI前后以及两个亚组血清CP-IgA、hs-CRP及Ang-2水平。分析血清CP-IgA、hs-CRP及Ang-2与PCI术后CHD患者预后的相关性。分析血清CP-IgA、 hs-CRP及Ang-2对PCI术后CHD患者预后的预测价值。结果:观察组血清CP-IgA、hs-CRP及Ang-2水平高于对照组(均P<0.05)。观察组患者PCI术后血清CP-IgA及Ang-2水平较PCI术前降低,血清hs-CRP水平较PCI术前升高(均P<0.05)。预后良好组患者血清CP-IgA、hs-CRP及Ang-2水平低于预后不良组(均P<0.05)。血清CP-IgA、hs-CRP及Ang-2与PCI术后CHD患者预后呈正相关(均P<0.05)。血清CP-IgA、hs-CRP及Ang-2单独预测PCI术后CHD患者预后的曲线下面积(AUC)小于三项联合(均P<0.05)。结论:CHD患者血清CP-IgA、hs-CRP及Ang-2水平升高,PCI术后血清CP-IgA和Ang-2水平降低,hs-CRP水平升高。预后不良患者血清CP-IgA、hs-CRP及Ang-2水平升高,且三者联合对PCI术后CHD患者预后的预测价值较高。
Objective:To explore the changes of serum chlamydia pneumoniae antibody-IgA(CP-IgA),hypersensitive C-reactive protein(hs-CRP)and angiogenin-2(Ang-2)levels and their predictive value of prognosis in patients with coronary heart disease(CHD)before and after percutaneous coronary intervention(PCI).Methods: A total of 135 CHD patients were selected as the observation group,and divided into good prognosis group(119 cases)and poor prognosis group(16 cases)according to the prognosis of the patients.Another 135 healthy subjects were selected as control group.The serum levels of CP-IgA,hs-CRP and Ang-2 were compared between the observation group and the control group,before and after PCI in the observation group and two subgroups.The correlation between serum CP-IgA,hs-CRP and Ang-2 and prognosis of CHD patients after PCI was analyzed.The prognostic value of serum CP-IgA,hs-CRP and Ang-2 in patients with CHD after PCI was analyzed.Results: The levels of CP-IgA,hs-CRP and Ang-2 in the observation group were higher than those in the control group(all P<0.05).The serum CP-IgA and Ang-2 levels in observation group were decreased after PCI,and the serum hs-CRP level was increased after PCI(all P<0.05).The levels of CP-IgA,hs-CRP and Ang-2 in the good prognosis group were lower than those in the poor prognosis group(all P<0.05).Serum CP-IgA,hs-CRP and Ang-2 were positively correlated with the prognosis of CHD patients after PCI(all P<0.05).The area under the curve(AUC)of serum CP-IgA,hs-CRP and Ang-2 independently predicted the prognosis of CHD patients after PCI was smaller than that of the three combinations(all P<0.05).Conclusion:Serum CP-IgA,hs-CRP and Ang-2 levels are increased in CHD patients,while serum CP-IgA and Ang-2 levels are decreased and hs-CRP level is increased after PCI.Serum CP-IgA,hs-CRP and Ang-2 levels are increased in patients with poor prognosis,and the combination of these three levels has a higher prognostic value in patients with CHD after PCI.
作者
刘永政
刘晓静
扈洁
王俊侠
刘平原
刘淑华
LIU Yongzheng;LIU Xiaojing;HU Jie;WANG Junxia;LIU Pingyuan;LIU Shuhua(Department of Cardiology,First Hospital of Qinhuangdao,Qinhuangdao 066000,China)
出处
《陕西医学杂志》
CAS
2024年第5期692-695,共4页
Shaanxi Medical Journal
基金
河北省医药卫生科技发展计划项目(202103012143)。
关键词
冠心病
经皮冠状动脉介入术
肺炎衣原体抗体IgA
超敏C-反应蛋白
血管生成素-2
预后
Coronary heart disease
Percutaneous coronary intervention
Chlamydia pneumoniae antibody-IgA
Hypersensitive C-reactive protein
Angiogenin-2
Prognosis
