摘要
目的 研究在急性胃炎的临床治疗中,应用奥美拉唑联合阿托品的治疗效果及不良反应发生情况。方法 选取2022年5月—2023年6月本院收治的急性胃炎患者中60例,以随机数表法将其分别纳入对照组与观察组,每组30例。对照组采用奥美拉唑单一治疗,观察组在奥美拉唑基础上联用阿托品,基于不同的治疗方案,对比两组的治疗效果、不良反应发生情况等。结果 观察组疗效高于对照组(P<0.05),不良反应发生率明显更低(P<0.05)。治疗前,两组TNF-α、IL-6、IL-8炎症因子水平对比无差异(P>0.05);治疗后,观察组与对照组水平均下降,且观察组明显较低(P<0.05)。对比两组患者胃炎症状改善时间,观察组各项症状改善用时明显较少(P<0.05)。结论 临床治疗急性胃炎,予以阿托品联合奥美拉唑,能够明显降低炎症因子水平,缩短患者症状改善时间,提高患者舒适度,保证临床治疗效果。同时,应用该治疗方案,有效降低了患者发生头痛、口干、心悸及肠胃不适等不良反应的风险,体现出较高的应用价值,值得临床推广应用。
Objective To study curative effect and incidence of adverse reactions of omeprazole combined with atropine in clinical treatment of acute gastritis.Methods The paper chose 60 patients with acute gastritis admitted to our hospital from May 2022 to June 2023,and divided them into control group and observation group with random number table method,with 30 cases in each group.Control group was treated with omeprazole monotherapy,while observation group with atropine in combination with omeprazole.Based on different treatment plans,treatment effect and incidence of adverse reactions was compared between two groups.Results Curative effect in observation group was higher than control group(P<0.05).Incidence of adverse reactions in control group was 43.33%,significantly higher than observation group,(P<0.05).Before treatment,there was no significant difference in levels of TNF-α,IL-6 and IL-8 inflammatory factors between two groups(P>0.05).After treatment,average water content in observation group and control group decreased,that of observation group was significantly lower(P<0.05).Improvement time of gastritis symptoms in observation group was significantly less than control group(P<0.05).Conclusion Atropine combined with omeprazole can significantly reduce levels of inflammatory factors,shorten time for symptom improvement,improve comfort,and ensure clinical treatment effectiveness in clinical treatment of acute gastritis.At the same time,the treatment plan reduces risk of adverse reactions effectively,including headache,dry mouth,palpitations,and gastrointestinal discomfort,which has high application value and is worthy of clinical promotion and application.
作者
何大友
HE Dayou(SUN Yat sen University the Fifth Affiliated Hospital,Zhuhai,Guangdong 519000)
出处
《智慧健康》
2024年第6期145-148,共4页
Smart Healthcare
关键词
奥美拉唑
阿托品
急性胃炎
不良反应
效果
Omeprazole
Atropine
Acute gastritis
Adverse reactions
Effect
