摘要
银屑病关节炎是具有自身免疫致病特征的慢性炎症性皮肤病,由慢性炎症引起,导致角质形成细胞生长不受控制,分化缺陷。肠道菌群与免疫系统调节之间的联系为许多慢性多因素疾病(包括银屑病关节炎)的发病机制开辟了一个新的角度。目前有研究表明,通过饮食方法和补充益生菌和益生原来调节肠道菌群,可能代表一种新的治疗方法。本文综述了有关银屑病患者肠道菌群改变的最新科学证据,以及肠道菌群靶向治疗作为银屑病关节炎预防和治疗工具的最新见解。
Psoriasis arthritis is chronic inflammatory skin disease with autoimmune pathogenic characteristics,caused by chronic inflammation,with uncontrolled growth of keratinocytes and differentiation defects.Relationship between gut microbiota and immune system regulation opened up new perspective on pathogenesis of many chronic multifactorial diseases,including psoriatic arthritis.Current evidence suggested regulating gut microbiota through dietary method and supplementing probiotics and prebiotics might represent a new curative approach.The article reviews the latest scientific evidence on changes in gut microbiota of psoriasis patients,and the latest insights into gut microbiota targeted therapy for prevention and treatment of psoriatic arthritis.
作者
王宝霞
WANG Baoxia(Department of Rheumatology and Immunology,Lanzhou University the Second Hospital,Lanzhou,Gansu 730030)
出处
《智慧健康》
2024年第5期126-129,共4页
Smart Healthcare
基金
甘肃省中医药管理局一般项目《黄连素缓释微球通过调节肠道菌群在银屑病关节炎中的作用研究》(项目编号:GZKP-2021-30)。
关键词
银屑病关节炎
肠道菌群
饮食方法
益生菌
作用机制
Psoriasis arthritis
Intestinal microbiota
Dietary methods
Probiotics
Mechanism of action
