摘要
目的 分析阿扎胞苷联合小剂量阿糖胞苷治疗老年急性白血病的效果。方法 选取2019年8月—2020年8月本院诊疗且符合研究标准的78例老年急性白血病患者为对象,应用数字双盲法分为对照组、试验组,每组39例。治疗过程中,对照组应用常规方案(CAG方案)治疗,试验组应用阿扎胞苷+小剂量阿糖胞苷治疗,比较各组免疫功能情况、临床疗效、外周血细胞变化情况、预后情况、不良反应发生率。结果 试验组治疗后CD3+、CD4+、CD4+/CD8+水平均较对照组高,NK细胞水平较对照组低,差异无统计学意义(P>0.05);试验组临床总有效率明显高于对照组,差异有统计学意义(P<0.05);试验组治疗后N、Hb、PLT水平均显著较对照组高,差异有统计学意义(P<0.05);试验组血小板恢复时间、中性粒细胞恢复时间均明显较对照组早,血小板输注量显著较对照组少,差异有统计学意义(P<0.05);试验组不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论 采取阿扎胞苷+小剂量阿糖胞苷治疗老年急性白血病具有确切的效果,能够改善机体外周血细胞水平,可促进治疗效果提升,对于免疫功能并无较大影响,且不良反应发生率较低,有利于改善预后情况,具有理想的联合用药效果,值得推广。
Objective To analyze effect of azacytidine combined with low-dose cytarabine in treatment of elderly acute leukemia.Methods The paper chose 78 elderly patients with acute leukemia met research criteria in our hospital from August 2019 to August 2020 as subjects,and divided them into control group and experimental group with digital double-blind method,with 39 cases in each group.During treatment process,control group was treated with routine scheme(CAG scheme),while experimental group with azacitidine and low-dose cytarabine.Immune function,clinical effect,peripheral blood cell changes,prognosis,and incidence of adverse reactions were compared between two groups.Results Levels of CD3+,CD4+,CD4+/CD8+ in experimental group were higher than control group after treatment,while levels of NK cells were lower than control group,with no statistically significant difference(P> 0.05).Total clinical effective rate of experimental group was significantly higher than control group,difference was statistically significant(P<0.05).After treatment,levels of N,Hb,and PLT in experimental group were significantly higher than control group,with statistical significance(P<0.05).Platelet recovery time and neutrophil recovery time of experimental group was significantly earlier than control group,and platelet infusion volume was significantly lower than control group,with statistical significance(P<0.05).in cidence of adverse reactions in experimental group was significantly lower than control group,difference was statistically significant(P< 0.05).Conclusion Combination of azacytidine and low-dose cytarabine can achieve definite effect for elderly acute leukemia,can improve level of peripheral blood cells in the body,improve treatment effect,with no significant effect on immune function and low incidence of adverse reactions,help improve prognosis with ideal combination drug effect,which is worthy of promotion.
作者
张如仙
焦银萍
杜悦欣
赵彩源
张冰歌
ZHANG Ruxian;JIAO Yinping;DU Yuexin;ZHAO Caiyuan;ZHANG Bingge(Hematology Department,Bayannur Traditional Chinese Medicine Hospital,Bayannur,in ner Mongolia 015000)
出处
《智慧健康》
2024年第3期167-170,共4页
Smart Healthcare
