摘要
目的探讨血清NSE、Hcy联合检测在急性脑梗死合并冠状动脉粥样硬化性心脏病中的价值。方法选取2019年10月~2022年10月在本院就诊的急性脑梗死患者30例(脑梗死组)、冠状动脉粥样硬化性心脏病(冠心病)患者30例(冠心病组)、急性脑梗死合并冠心病患者32例(合并组),同时期选取体检正常的健康人30名(对照组)。依据疾病严重程度分为轻度组、中度组、重度组。随访6个月,根据预后情况分为预后不良组、预后良好组。酶联免疫吸附试验检测血清NSE、Hcy水平。统计四组基础资料、血清NSE、Hcy水平,分析合并组疾病严重程度及预后分别与NSE、Hcy水平的关系,多因素的Logistic回归分析预后不良因素,并经ROC曲线分析血清NSE、Hcy联合检测对预后不良的预测价值。结果四组血清NSE、Hcy比较存在显著差异(P<0.05),合并组最高,脑其次梗死组、冠心病组(P<0.05);重度组NSE、Hcy水平最高,中度组次之,轻度组最低;预后良好组与预后不良组NSE、Hcy水平比较,P<0.05;血清NSE、Hcy联合预测价值更高(P<0.05)。结论血清NSE、Hcy联合检测急性脑梗死合并冠状动脉粥样硬化性心脏病可预测患者病情和预后。
Objective To investigate the value of serum NSE and Hcy combined detection in acute cerebral infarction complicated with coronary atherosclerotic heart disease.Methods From October 2019 to October 2022,30 patients with acute cerebral infarction(cerebral infarction group),30 patients with coronary atherosclerotic heart disease(coronary heart disease group),32 patients with acute cerebral infarction combined with coronary heart disease(combined group)were selected from our hospital,and 30 healthy people with normal physical examination(control group)were selected during the same period.According to the severity of the disease,they were divided into mild group,moderate group and severe group.The patients were followed up for 6 months and divided into poor prognosis group and good prognosis group according to the prognosis.Serum NSE and Hcy levels were detected by enzyme-related immunosorbent assay.Basic data,serum NSE and Hcy levels of the four groups were analyzed,and the relationship between disease severity and prognosis of the combined group and the levels of NSE and Hcy were analyzed.Multivariate Logistic regression was used to analyze the adverse prognostic factors,and the predictive value of serum NSE and Hcy combined detection for poor prognosis was analyzed by ROC curve.Results There were significant differences in serum NSE and Hcy among the four groups(P<0.05),and the highest values were found in the combined group,the secondary cerebral infarction group and the coronary heart disease group(P<0.05).The levels of NSE and Hcy were the highest in severe group,followed by moderate group,and the lowest in mild group.The levels of NSE and Hcy in good prognosis group and poor prognosis group were compared,P<0.05;The combined prediction value of serum NSE and Hcy was higher(P<0.05).Conclusion Combined detection of serum NSE and Hcy can predict the condition and prognosis of patients with acute cerebral infarction complicated with coronary atherosclerotic heart disease.
作者
刘明梅
岳志城
刘明皎
LIU Ming-mei;YUE Zhi-cheng;LIU Ming-jiao(Laboratory of Luoyang Traditional Chinese Medicine Hospital,Luoyang 471000,Henan Province,China;Department of Emergency,Luoyang Central Hospital Afliated to Zhengzhou University,Luoyang 471000,Henan Province,China;Department of Pathology,First Afliated Hospital of Henan University of Science and Technology Luoyang 471000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第5期21-23,共3页
Journal of Rare and Uncommon Diseases
