摘要
目的探究氨溴索联合布地奈德对新生儿肺炎(pneumonia,PN)的疗效。方法随机选取119例PN新生儿,采用随机数表法分为观察组(59例)和对照组(60例),对照组患儿采用布地奈德单药雾化治疗,观察组在对照组治疗的基础上联合氨溴索静脉滴注。对比2组患儿的治疗疗效、临床症状消失时间、不良反应以及外周血指标表达水平。结果观察组治疗总有效率高于对照组,治疗后6个月复发率低于对照组,发热、咳嗽、气喘消失时间以及住院时间均短于对照组(P<0.05)。2组不良反应总发生率比较差异无统计学意义。与对照组比较,观察组治疗后血清干扰素-γ(interferon-γ,IFN-γ)、谷胱甘肽氧化物酶(glutathione peroxidase,GSH-PX)、超氧化物歧化酶(superoxide dismutas,SOD)高于对照组,白细胞介素-17(interleukin-17,IL-17)低于对照组,P<0.05。结论氨溴索联合布地奈德治疗新生儿PN的临床疗效优于布地奈德单药治疗,同时可显著改善患儿的免疫功能,促进康复,且在一定程度上能降低短期内的复发率。
Objective To analyze the efficacy of ambroxol combined with budesonide on neonatal pneumonia(PN).Methods 119 newborns with PN were randomly selected and divided into observation group(59 cases)and control group(60 cases)by random number table method.The children in the control group were treated with budesonide single-drug atomization treatment,while the observation group was combined with ambroxol intravenous infusion on this basis.The therapeutic efficacy,disappearance time of clinical symptoms,adverse reactions and expression levels of peripheral blood indicators were compared between the 2 groups.Results The total effective rate in the observation group was higher than that in the control group,the recurrence rate 6 months after treatment was lower than that in the control group,the disappearance time of fever,cough,asthma and hospital stay were shorter than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the 2 groups(P>0.05).Compared with the control group,the serum interferon-γ(IFN-γ),glutathione oxidase(GSH-PX),superoxide dismutas(SOD)in the observation group after treatment was higher than that in the control group,and the serum concentrations of interleukin-17(IL-17)were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The clinical efficacy of ambroxol combined with budesonide in the treatment of PN is better than that of budesonide monotherapy.At the same time,the combination regime can significantly improve the immune function of children,promote recovery,and reduce the short-term recurrence rate to a certain extent.
作者
代丽
曾燕
高阳
DAI Li;ZENG Yan;GAO Yang(Department of Pediatrics,Deyang City People’s Hospital,Deyang 618000,China)
出处
《西北药学杂志》
CAS
2024年第3期173-177,共5页
Northwest Pharmaceutical Journal
基金
德阳市社会发展领域创新指导项目(编号:2022SCZ134)。
关键词
新生儿肺炎
氨溴索
布地奈德
疗效
免疫功能
neonatal pneumonia
ambroxol
budesonide
efficacy
immune function
