摘要
目的探究达格列净对老年2型糖尿病(type 2 diabetes mellitus,T2DM)合并射血分数保留型心力衰竭(heart failure with preserved ejection fraction,HF-PEF)患者心、肾功能的影响。方法选择老年T2DM合并HF-PEF患者200例作为研究对象,用随机数字表法分为观察组和对照组,每组100例。对照组用常规治疗方式治疗,观察组在对照组治疗的基础上联合达格列净进行治疗。比较2组治疗前、后的血糖水平、心功能、肾功能、炎症因子水平,记录2组不良反应的发生情况。结果治疗后,2组的空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2 hours postprandial blood glucose,2 hPG)、血红蛋白(glycosylated hemoglobin Alc,HbAlc)水平均低于治疗前(P<0.05)。治疗后,2组的左心室射血分数(left ventricular ejection fraction,LVEF)、6 min步行试验水平均高于治疗前,且观察组[(46.35%±7.02%)、(364.91±23.65)m]均高于对照组[(42.18%±7.43%)、(315.47±26.52)m],P<0.05,2组的左心室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心室舒张早期二尖瓣血流最大速度(E)/舒张早期二尖瓣环峰值速度(e’)水平均低于治疗前,且观察组[(50.36±6.05)mm、(8.25±1.03)]均低于对照组[(54.01±6.84)mm、(10.15±1.24)],P<0.05。治疗后,观察组的血肌酐(serum creatinine,Cr)、血尿酸(uric acid,UA)、胱抑素C(cystatin C,Cys-C)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1β,IL^(-1)β)水平[(46.58±6.14)μmol·L^(-1)、(241.52±41.05)μmol·L^(-1)、(0.68±0.11)mg·L^(-1)、(1.71±0.48)mg·L^(-1)、(10.22±1.05)ng·L^(-1)、(32.48±4.62)ng·L^(-1)]均低于对照组[(67.25±6.38)μmol·L^(-1)、(305.71±53.42)μmol·L^(-1)、(0.76±0.15)mg·L^(-1)、(2.13±0.57)mg·L^(-1)、(18.43±1.26)ng·L^(-1)、(49.51±5.17)ng·L^(-1)],P<0.05。2组不良反应发生率分别为4.00%、6.00%,差异无统计学意义(P>0.05)。结论达格列净可改善老年T2DM合并HF-PEF患�
Objective To explore the effects of dapagliflozin on cardiac and renal function in elderly patients with type 2 diabetes mellitus(T2DM)and heart failure with preserved ejection fraction(HF-PEF).Methods A total of 200 elderly patients with T2DM and HF-PEF were enrolled as the research objects.According to random number table method,they were divided into observation group(n=100)and control group(n=100).The control group was given routine treatment,while the observation group was additionally treated with dapagliflozin.The blood glucose level,cardiac function,renal function and inflammatory factors were compared between the 2 groups before and after treatment.The occurrence of adverse reactions in both groups was recorded.Results After treatment,the levels of fasting blood glucose(FBG),2 hours postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbAlc)were decreased in both groups(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)and 6 minutes walking distance were increased in both groups,which in observation group were(46.35%±7.02%)and(364.91±23.65)m,higher than those in control group[(42.18%±7.43%),(315.47±26.52)m,P<0.05].After treatment,the left ventricular end-diastolic diameter(LVEDD)and the ratio of early diastolic transmitral velocity to early diastolic mitral annular velocity(E/e’)were decreased in both groups,which in observation group were(50.36±6.05)mm and(8.25±1.03),lower than those in control group[(54.01±6.84)mm,(10.15±1.24),P<0.05].After treatment,the levels of serum creatinine(Cr),uric acid(UA),cystatin C(Cys-C),C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-1β(IL^(-1)β)in observation group were(46.58±6.14)μmol·L^(-1),(241.52±41.05)μmol·L^(-1),(0.68±0.11)mg·L^(-1),(1.71±0.48)mg·L^(-1),(10.22±1.05)ng·L^(-1) and(32.48±4.62)ng·L^(-1),lower than those in control group[(67.25±6.38)μmol·L^(-1),(305.71±53.42)μmol·L^(-1),(0.76±0.15)mg·L^(-1),(2.13±0.57)mg·L^(-1),(18.43±1.26)ng·L^(-1),(49.51±5.17)ng·L^(-1),P<0.05].The difference i
作者
江煜旻
黄岚
冯涛
JIANG Yumin;HUANG Lan;FENG Tao(Department of Pharmacy,Nanjing Central Hospital,Nanjing 210018,China)
出处
《西北药学杂志》
CAS
2024年第3期110-114,共5页
Northwest Pharmaceutical Journal
基金
江苏省卫生健康委员会项目(编号:LKM2023028)。
关键词
2型糖尿病
达格列净
射血分数保留型心力衰竭
心功能
肾功能
type 2 diabetes mellitus
dapagliflozin
heart failure with preserved ejection fraction
cardiac function
renal function
