摘要
目的优化复方黄栀连颗粒的提取工艺。方法以黄芩苷含量为评价指标,用单因素实验确定加水量、提取时间、提取次数的因素水平;以干膏率及黄芩苷含量综合分值为评价指标,用L_(9)(3^(4))正交试验筛选复方黄栀连颗粒的最佳提取工艺。结果最优提取工艺为加12倍水,提取3次,每次1 h。结论该提取方法便于操作,稳定可靠,重复性好。
Objective To optimize the extraction process of Compound Huangzhilian Granules.Methods By taking the content of baicalin as an indicator,single factor tests were used to choose the three levels of amount of water,extraction time and extraction times.By taking the comprehensive scores of the dry extract rate and the content of baicalin as indicators,an L_(9)(3^(4))of orthogonal experiment was used to optimize the extraction process.Results The optimized extraction conditions were 12 times amount of water and extracted for 3 times with 1 hour for each time.Conclusion The optimized extraction process is stable and feasible with good reproducibility.
作者
袁曼
谢世孔
叶文君
谢巧娥
YUAN Man;XIE Shikong;YE Wenjun;XIE Qiaoe(Department of Pharmacy,the Sixth People’s Hospital of Dongguan,Dongguan 523008,China)
出处
《西北药学杂志》
CAS
2024年第3期77-81,共5页
Northwest Pharmaceutical Journal
基金
东莞市社会发展科技项目(编号:20211800900972)。
关键词
复方黄栀连颗粒
正交试验
黄芩苷
提取工艺
Compound Huangzhilian Granules
orthogonal experiment
baicalin
extraction process
