摘要
目的对结直肠癌围术期静脉血栓栓塞(VTE)发生的相关影响因素进行研究,以指导预防和治疗。方法研究为前瞻性队列研究,纳入2021年6月—2022年4月在本院行结直肠癌根治术的102例患者,获取暴露指标,并观察结局,采用单因素分析和多因素Logistic回归分析结直肠癌围术期发生静脉血栓栓塞的影响因素。结果纳入者中共有20例患者在围术期发生了VTE。经单因素分析,两组患者在年龄、是否合并有糖尿病、既往VTE病史等方面比较,差异有统计学意义(P<0.05);在性别、BMI、是否合并冠心病、是否合并高血压、术前4周是否行抗凝治疗、手术方式、手术时间、手术体位、术后是否行物理预防、术后实验室检查指标上差异无统计学意义(P>0.05)。多因素Logistic回归分析得出年龄与结直肠癌围术期并发VTE有回归关系(P=0.005,OR=1.136)。结论结直肠癌围手术期的VTE发生率高达19.6%;对于年龄(72.95±9.44)岁以上、患有糖尿病、既往有VTE病史的患者,围术期应当加强干预措施,预防静脉血栓栓塞的形成,对于手术时间、手术体位等更值得关注的指标,还需要本中心更大的样本来进一步说明。
Objective To investigate the risk factors of perioperative venous thromboembolism(VTE)in patients with colorectal cancer.Methods This study was a prospective cohort study,including 102 patients who underwent radical resection of colorectal cancer in Nanchong Central Hospital Affiliated to North Sichuan Medical College from June 2021 to April 2022.Exposure indicators were obtained and outcomes were observed.Univariate analysis and multivariate Logistic regression were used to analyze the influencing factors of venous thromboembolism during perioperative period of colorectal cancer.Results Of the 102 patients included,a total of 20 patients experienced VTE during the perioperative period.Univariate analysis showed that there were statistically significant differences between the two groups in terms of age,diabetes mellitus and past history of VTE(P<0.05),while there were no statistically significant differences in terms of gender,BMI,coronary heart disease,hypertension,anticoagulation therapy 4 weeks before operation,operation mode,operation time,operation position,physical prophylaxis after operation and postoperative laboratory examination indicators.Multivariate Logistic regression analysis showed that age was associated with VTE(P=0.005,OR=1.136).Conclusion The incidence of VTE in perioperative period of colorectal cancer is 19.6%.For patients over the age of(72.95±9.44)with diabetes mellitus and a history of VTE,perioperative intervention measures should be strengthened to prevent the formation of VTE,and more noteworthy indicators such as operation time and operation position should be considered.
作者
敬荣
周冬兵
郭炜
郭庆
张大权
滕庆
杨选华
秦龙
李权林
吕真冰
任明扬
JING Rong;ZHOU Dongbin;GUO Wei;GUO Qing;ZHANG Daquan;TENG Qing;YANG Xuanhua;QIN Long;LI Quanlin;LYU Zhenbing;REN Mingyang(Department of Gastrointestinal Surgery,Nanchong Central Hospital,The Second Clinical Institute of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
出处
《西部医学》
2024年第5期734-738,共5页
Medical Journal of West China
基金
国家自然科学基金资助项目(81401927)
四川省医学科研课题计划(S19049)
四川省医学科研课题计划(S21082)
南充市市校合作科研专项(19SXHZ0452)。
关键词
结直肠癌
围术期
静脉血栓栓塞
危险因素
Colorectal cancer
Perioperative period
Venous thromboembolism
Risk factors
