摘要
目的:观察吸入性乙酰半胱氨酸联合莫西沙星治疗重症肺炎患者的效果。方法:选取2022年1月至2023年8月该院收治的80例重症肺炎患者进行前瞻性研究,按照随机数字表法将其分为对照组与研究组各40例。对照组采用盐酸莫西沙星片治疗,研究组在对照组基础上联合吸入用乙酰半胱氨酸溶液治疗,比较两组治疗效果,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))]水平、呼吸力学指标[最大呼气流量(PEF)、达峰容积比(VPEF/VE)、潮气容积(VT)、达峰时间比(TPTEF/TE)]水平、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,两组FVC、FEV_(1)水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组PEF、VPEF/VE、VT、TPTEF/TE水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6、PCT水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:吸入性乙酰半胱氨酸联合莫西沙星治疗重症肺炎患者可提高治疗总有效率、肺功能指标水平和呼吸力学指标水平,降低炎性因子水平,其效果优于单纯莫匹沙星治疗。
Objective:To observe effects of inhaled Acetylcysteine combined with Moxifloxacin in treatment of patients with severe pneumonia.Methods:A prospective study was conducted on 80 patients with severe pneumonia admitted to the hospital from January 2022 to August 2023.According to the random number table method,they were divided into control group and study group,40 cases in each group.The control group was treated with Moxifloxacin hydrochloride tablets,while the study group was treated with Acetylcysteine solution for inhalation on the basis of the control group.The therapeutic effects,the levels of lung function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))],respiratory mechanics indexes[maximum expiratory flow(PEF),ratio of volume at peak tidal expiratory flow to expiratory tidal volume(VPEF/VE),tidal volume(VT)and ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE)],and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),procalcitonin(PCT)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.00%(38/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FVC and FEV_(1) in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PEF,VPEF/VE,VT and TPTEF/TE in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-6 and PCT in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,ther
作者
白烛亮
BAI Zhuliang(Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000 Henan,China)
出处
《中国民康医学》
2024年第8期36-38,42,共4页
Medical Journal of Chinese People’s Health
关键词
乙酰半胱氨酸
重症肺炎
肺功能
呼吸力学
炎性因子
不良反应
Acetylcysteine
Severe pneumonia
Lung function
Respiratory mechanics
Inflammatory factor
Adverse reaction
