摘要
目的:探讨鼠神经生长因子(mNGF)联合低剂量重组人促红细胞生成素(rh Epo)对早产儿脑损伤后神经发育的影响。方法:选取2021年3月~2022年3月期间某院收治的200例脑损伤早产儿作为研究对象,依据随机数字表法分为对照组和观察组,每组100例。两组患儿均给予营养支持、水电解质纠正、血糖、血压维持等常规治疗,对照组在常规治疗基础上给予注射用鼠神经生长因子,观察组在对照组治疗基础上静脉注射低剂量重组人促红素注射液(CHO细胞)。比较两组患儿脑损伤相关因子[神经元特异性烯醇化酶(NSE)、S100钙结合蛋白β(S100β)、8-羟基脱氧鸟苷(8-OHdG)、8-异前列腺素F2α(8-iso-PGF2α)]、炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-18(IL-18)、Toll样受体4(TLR4)]水平、神经发育异常情况、智能等级及不良反应发生情况。结果:治疗后,两组患儿NSE、S100β、8-OHdG、8-iso-PGF2α水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组患儿TNF-α、IL-18、TLR4水平均降低(P<0.05),且观察组低于对照组(P<0.05);观察组患儿神经发育异常项目≥3项及异常项目≥1项的发生率均低于对照组(P<0.05);两组患儿智能等级均呈升高趋势(P<0.05),且观察组升高趋势更明显(P<0.05);两组患儿不良反应总发生率比较无统计学差异(P>0.05)。结论:在常规治疗基础上联用m NGF、低剂量rhEpo可有效降低患儿脑损伤相关因子水平及神经发育异常率,提高智能等级,且未增加不良反应的发生风险。
Objective:To investigate the effects of mouse nerve growth factor(mNGF)combined with low dose recombinant human erythropoietin(rhEpo)on neurodevelopment in preterm infants with brain injury.Methods:A total of 200 preterm infants with brain injury,admitted to a hospital from March 2021 to March 2022 were assigned into the control group and the observation group using random number table method,with 100 cases in each group.Both groups were given standard treatment such as nutritional support,electrolyte correction,as well as blood glucose and blood pressure maintenance.The control group was given mouse nerve growth factor for injection in addition to standard treatment,and the observation group was injected intravenously with low dose recombinant human erythropoietin injection(CHO cell)in addition to the control group treatment.The levels of brain injury related factors[neuron-specific enolase(NSE),S100 calcium binding proteinβ(S100β),8-hydroxydeoxyguanosine(8-OHdG),8-iso-prostaglandin F2α(8-iso-PGF2α)],inflammatory factor[tumor necrosis factor-α(TNF-α),interleukin-18(IL-18),Toll-like receptor 4(TLR4)],neurodevelopmental abnormalities,intelligence grades and adverse reactions were compared between the two groups.Results:Following treatment,the levels of NSE,S100β,8-OHdG and 8-iso-PGF2αdecreased in both groups(P<0.05),with the observation group showing lower levels than the control group.The levels of TNF-α,IL-18 and TLR4 decreased in both groups(P<0.05),with the observation group showing lower levels than the control group(P<0.05).The incidences of neurodevelopmental abnormalities with grades≥3 and≥1 were lower in the observation group compared to the control group(P<0.05).The intelligence level of the children in both groups showed an increasing trend(P<0.05),and the increasing trend was more obvious in the observation group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On that basis of standard treatment,mNGF
作者
吴珺珺
吴斌
文艺
田丽
WU Jun-jun;WU Bin;WEN Yi;TIAN Li(Department of Child Health Care,Zhoukou City Center Hospital,Zhoukou 466000,China;Department of Pediatrics,Henan Hospital of Integrated Traditional Chinese and Western Medicine,Zhengzhou 450000,China)
出处
《中国合理用药探索》
CAS
2024年第4期63-68,共6页
Chinese Journal of Rational Drug Use
关键词
早产儿
脑损伤
神经发育
鼠神经生长因子
重组人促红细胞生成素
脑损伤相关因子
智能等级
安全性
preterm infant
brain injury
neurodevelopment
mouse nerve growth factor
recombinant human erythropoietin
brain injury related factors
intelligence level
safety
