摘要
目的探讨急慢性血糖比值与急性心肌梗死(AMI)合并2型糖尿病(T2DM)经皮冠状动脉介入治疗(PCI)预后结局的关系。方法对接受PCI的112例AMI合并T2DM患者随访2 a(以患者死亡为随访终点),根据随访结果分为生存组与死亡组。采用单因素分析及多因素Logistic回归分析探讨AMI合并T2DM患者PCI预后的影响因素,绘制受试者工作特征(ROC)曲线评估急慢性血糖比值对AMI合并T2DM患者PCI预后不良的预测效能。结果随访2 a,112例患者死亡13例(11.61%),生存99例(88.39%),随访期间发生不良心血管事件17例(15.18%)。两组患者三酰甘油、高密度脂蛋白、急性血糖、糖化血红蛋白水平及急慢性血糖比值比较,差异有统计学意义(P<0.05或0.01)。急慢性血糖比值是影响AMI合并T2DM患者PCI预后不良的独立危险因素(P<0.01)。ROC曲线显示,急慢性血糖比值对AMI合并T2DM患者PCI预后不良预测的灵敏度为60.57%、特异度为72.89%,曲线下面积为0.688,截断值为1.293。结论急慢性血糖比值是AMI合并T2DM患者PCI预后不良的独立危险因素,对预后结局具有较好的预测价值。
Objective To explore the relationship of acute-to-chronic glycemic ratio(ACGR)with the prognosis in patients with acute myocardial infarction(AMI)complicated by type 2 diabetes mellitus(T2DM)undergoing percutaneous coronary intervention(PCI).Methods A total of 112 patients with AMI and T2DM undergoing PCI were followed up for 2 years(death was the end point of follow-up)and were divided into survival and death group according to follow-up results.Influencing factors of prognosis were explored using univariate analysis and multivariate Logistic regression analysis and receiver operating characteristic(ROC)curves were plotted to assess the value of ACGR predicting poor prognosis.Results During 2-year follow-up,13(11.61%)of the 112 patients died,99(88.39%)survived,and 17(15.18%)developed adverse cardiovascular events during follow-up.Intergroup differences in triacylglycerol,high-density lipoprotein,acute blood glucose,and glycosylated hemoglobin levels as well as the ACGR were statistically significant(P<0.05 or 0.01).The ACGR was an independent risk factor for poor prognosis of AMI patients with T2DM undergoing PCI(P<0.01).ROC curve showed that the sensitivity and specificity of the ACGR predicting poor prognosis were respectively 60.57%and 72.89%,the area under the curve was 0.688,and cutoff value 1.293.Conclusion The ACGR is an independent risk factor for poor prognosis of AMI patients with T2DM undergoing PCI and has a better predictive value for the prognosis in patients with AMI plus T2DM undergoing PCI.
作者
李洁
杨宁波
杨一帆
Li Jie;Yang Ningbo;Yang Yifan(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2024年第3期56-59,共4页
Journal of Clinical Psychosomatic Diseases
基金
河南省医学教育研究项目(编号Wjlx2020454)。
