摘要
目的:探究应用特布他林+布地奈德治疗重症慢性阻塞性肺疾病急性加重(AECOPD)患者的临床疗效。方法:选取2020年2月至2023年3月太仓市第一人民医院重症AECOPD患者84例作为研究对象,按照随机数字表法分为对照组和观察组,每组42例。对照组患者在常规治疗基础上给予硫酸特布他林雾化吸入治疗,观察组患者在对照组治疗基础上联合布地奈德混悬液共同进行雾化治疗,比较2组不同用药方法对患者炎症介质、睡眠质量以及临床疗效等方面的影响。结果:治疗前2组炎症介质水平比较,差异均无统计学意义(均P>0.05),治疗后观察组患者C-反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)水平低于对照组,差异均有统计学意义(均P<0.05);治疗前2组患者睡眠质量差异无统计学意义(P>0.05),治疗后观察组患者睡眠时间、觉醒次数和匹兹堡睡眠质量指数(PSQI)评分明显优于对照组,差异均有统计学意义(均P<0.05);观察组患者临床疗效率明显高于对照组,差异有统计学意义(P<0.05);治疗前2组患者肺功能,差异均无统计学意义(均P>0.05),治疗后观察组患者用力呼气容积(FEV_1)、用力肺活量(FVC)、最大呼气中期流速(MMEF)和呼气峰流速(PEF)水平均高于对照组,差异均有统计学意义(均P<0.05)。结论:通过对重症AECOPD患者开展联合用药治疗(特布他林+布地奈德)后,可达到显著临床治疗效果,对于机体健康恢复有着积极作用。
Objective:To explore the clinical efficacy of terbutaline plus budesonide in the treatment of severe acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients.Methods:A total of 84 patients with severe AECOPD from February 2020 to March 2023 at the First People′s Hospital of Taicang City were selected as the study subjects,and were randomly divided into a control group and an observation group with 42 cases in each group,using a random number table method.The control group patients were given nebulized inhalation therapy of terbutaline sulfate on the basis of routine treatment,while the observation group patients were given nebulized therapy in combination with budesonide suspension on the basis of control group treatment.The effects of different medication methods on inflammatory mediators,sleep quality,and clinical efficacy of the two groups were compared.Results:There was no significant difference in the levels of inflammatory mediators between the two groups before treatment(P s>0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),and procalcitonin(PCT)in the observation group were lower than those in the control group,and the difference was statistically significant(P s<0.05).There was no statistically significant difference in sleep quality between the two groups of patients before treatment(P>0.05).After treatment,the observation group had significantly better sleep time,number of awakenings,and Pittsburgh Sleep Quality Index(PSQI)scores than the control group,with statistically significant differences(P s<0.05).The clinical treatment efficiency of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in lung function between the two groups of patients(P s>0.05).After treatment,the observation group had higher levels of forced expiratory volume(FEV 1),forced vital capacity(FVC),maximum mid expiratory flow rate(MMEF
作者
王爱民
殷辰俞
朱广兵
WANG Aimin;YIN Chenyu;ZHU Guangbing(The First People′s Hospital of Taicang City,Taicang 215400,China)
出处
《世界睡眠医学杂志》
2024年第2期272-274,共3页
World Journal of Sleep Medicine
关键词
重症慢性阻塞性肺疾病急性加重
特布他林
布地奈德
炎症介质
睡眠质量
Severe acute exacerbation of chronic obstructive pulmonary disease(AECOPD)
Terbutaline
Budesonide
Inflammatory mediators
Sleep quality
