摘要
目的探究不同时效重组人生长激素治疗生长激素缺乏症(GHD)儿童的临床效果、代谢影响及不良事件发生情况。方法选取GHD儿童114例,分为长效组[聚乙二醇化重组人生长激素(PEG-rhGH)治疗,n=50]及短效组[重组人生长激素(rhGH)治疗,n=64],收集2组儿童治疗前一般资料,比较两组儿童治疗第3、6、9、12月时的生长速率(GV)、生长标准差积分(Ht SDS)、血清胰岛素样生长因子-1(IGF-1)及其他血清学指标,观察治疗期间不良事件发生情况。结果2组GHD儿童经治疗后GV、Ht SDS、IGF-1均较治疗前升高,差异有统计学意义(P<0.05);治疗12月时长效组儿童Ht SDS高于短效组(P<0.05),GV、IGF-1高于短效组、但差异无统计学意义(P>0.05);2组儿童治疗后各血清学指标均在正常范围内,与治疗前比较差异无统计学意义(P>0.05),且两组组间比较差异无统计学意义(P>0.05);短效组不良事件发生率高于长效组,注射局部发生红肿硬结的不良事件高于长效组,差异有统计学意义(P<0.05)。结论长效和短效rhGH对GHD儿童均有显著疗效,对肝肾功能、糖脂代谢、血清蛋白、甲状腺功能影响小,安全性较好;长效药物可使早期身高获益,且治疗期间不良事件发生率低。
Objective To explore the clinical efficacy,metabolic effect and adverse events of recombinant human growth hormone with different acting time in treating children with growth hormone deficiency(GHD).Methods A total of 114 children with GHD were selected and divided into a long acting group[treated with polyethylene glycol recombinant human growth hormone(PEG-rhGH),n=50]and a short acting group[treated with recombinant human growth hormone(rhGH),n=64].General information was collected from two groups of children before treatment.Growth velocity(GV),height standard deviation score(Ht SDS),serum insulin-like growth factor-1(IGF-1),and other serological indicators were compared between two groups at 3 rd,6 th,9 th,and 12 th months of treatment.Results After treatment,GV,Ht SDS,and IGF-1 level were increased significantly in two groups of the children with GHD when compared to before treatment(P<0.05).Ht SDS was higher in long acting group than that in short acting group(P<0.05).GV and IGF-1 were a little bit higher in long acting group than those in short acting group(P>0.05).After treatment,all serological indicators of the children in two groups were within the normal ranges,with no statistically significant differences when compared to before treatment(P>0.05).There were no statistically significant differences in all serological indicators between two groups(P>0.05).The incidence of adverse events in short acting group was higher than those in the long acting group(P<0.05).Conclusion Both long-and short-acting rhGH exert significant effects on children with growth hormone deficiency and very little effect on liver and kidney functions,glucose and lipid metabolism,serum proteins and thyroid function,with good safety.Long-acting rhGH can benefit early height gain with low incidence of adverse events during treatment.
作者
张雪
罗昭逊
艾戎
ZHANG Xue;LUO Zhaoxun;AI Rong(Department of Pediatrics,the Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou,China;School of Clinical Medicine,Guizhou Medical University,Guiyang 550001,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2024年第4期596-602,共7页
Journal of Guizhou Medical University
基金
贵州省卫生健康委科学技术基金项目(gzwkj2021-287)。
