摘要
三阴性乳腺癌属于免疫原性较强的乳腺癌亚型,由于缺乏有效的治疗靶点,仍属于难以治疗的乳腺癌类型。越来越多的研究表明,肠道菌群可通过干预宿主或微生物的色氨酸代谢,重塑肿瘤免疫微环境,从而影响三阴性乳腺癌的发生、发展及免疫治疗疗效。中药在以往的研究中已被证实可以有效调节肠道稳态,抑制炎症反应,促进肿瘤细胞的凋亡等。然而,肠道菌群及其代谢物与三阴性乳腺癌之间的中医机制尚不明确。因此,本文在中医辨证乳腺癌基础理论的基础上,回顾以往的文献,从肠道菌群和色氨酸代谢的角度出发,梳理中药对肠道菌群及其代谢物质的干预作用,探索其抗肿瘤的机制,以期能为中西医结合治疗三阴性乳腺癌提供新的思路和方法。
Triple-negative breast cancer(TNBC)is a subtype of breast cancer with strong immunogenicity.Due to lack of effective therapeutic targets,TNBC is still a refractory type of breast cancer.More and more studies have shown that gut microbiota can influence the occurrence and development of TNBC,and the efficacy of immunotherapy by intervening the tryptophan metabolism of host or microorganisms and reshaping the tumor immune microenvironment.Traditional Chinese medicine(TCM)has been proved to be effective in promoting cell apoptosis,regulating intestinal homeostasis and inhibiting inflammatory responses in TNBC in previous studies.However,the mechanisms of TCM intervening gut microbiota and its metabolites and TNBC remain unclear.Therefore,on the basis of basic TCM theory of syndrome differentiation of breast cancer and in the perspective of gut microbiota and tryptophan metabolisms,this article reviewed previous literatures,summarized the intervening effect of TCM on gut microbiota and its metabolites,and explored its anti-tumor mechanisms,hoping to provide new ideas and methods for the treatment of TNBC with integrated TCM and western medicine.
作者
王怡
孙霃平
秦悦农
吴春宇
郝炜
张洋
李斐斐
刘胜
WANG Yi;SUN Chenping;QIN Yuenong;WU Chunyu;HAO Wei;ZHANG Yang;LI Feifei;LIU Sheng(The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310060,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
北大核心
2024年第3期363-367,共5页
Chinese Journal of Microecology
基金
上海市三年行动计划-重大疾病多中心临床研究项目(SHDC2020CR1050B)
上海市2020年度“科技创新行动计划”(20Z21900300)。
关键词
中药
肠道菌群
色氨酸代谢
肿瘤微环境
三阴性乳腺癌
免疫治疗
Traditional Chinese medicine
Gut microbiota
Tryptophan metabolism
Tumor microenvironment
Triplenegative breast cancer
Immunotherapy
