摘要
目的:观察桂枝茯苓胶囊对早期子宫内膜癌患者腹腔镜术后恢复及炎症介质水平的影响。方法:选取2019年6月至2022年5月在徐州市中心医院进行治疗的早期子宫内膜癌患者80例作为研究对象,采取简单随机法分为观察组和对照组,每组40例。对照组予以腹腔镜治疗,观察组术后联合桂枝茯苓胶囊治疗,3粒/次,3次/d,饭后吞服,治疗3个月。比较2组患者疾病缓解率、术后恢复情况[术后1、3、7 d的视觉模拟评分(VAS)及膀胱功能恢复时间、住院时间]、手术前及术后3个月中医证候积分和相关血清指标[糖类抗原(CA)125、人附睾分泌蛋白4(HE4)、白细胞介素-4(IL-4)、IL-6]以及术后并发症发生情况。结果:观察组总疾病缓解率为90.00%,高于对照组的72.50%(P<0.05);观察组术后3、7 d的VAS均低于对照组,膀胱功能恢复时间和住院时间均短于对照组(均P<0.05)。术后3个月,观察组的中医证候积分均低于对照组(均P<0.05),血清CA125、HE4、IL-6水平均低于对照组(均P<0.05),IL-4水平高于对照组(P<0.05)。2组术后并发症发生率比较差异无统计学意义(P>0.05)。结论:桂枝茯苓胶囊可有效降低早期子宫内膜癌患者腹腔镜术后肿瘤标志物及机体炎症介质水平,促进术后恢复,提高临床缓解率。
Objective:To observe the effects of Guizhi Fuling Capsules on the postoperative recovery and levels of inflammatory mediators in patients with early endometrial cancer after laparoscopy.Methods:Eighty patients with early endometrial cancer treated at Xuzhou Central Hospital from June 2019 to May 2022 were enrolled and randomly divided into an observation group and a control group,with 40 cases in each group.The control group received laparoscopy,while the observation group received postoperative treatment with Guizhi Fuling Capsules,3 capsules per time,3 times a day,taken orally after meals for 3 months.The disease remission rate,postoperative recovery [Visual Analogue Scale(VAS) scores at 1,3,and 7 days postoperatively,bladder function recovery time,and length of hospital stay],traditional Chinese medicine(TCM) syndrome scores,and related serum indicators [cancer antigen(CA) 125,human epididymis protein 4(HE4),interleukin-4(IL-4),and IL-6] before surgery and 3 months after surgery,as well as the incidence of postoperative complications,were compared between the two groups.Results:The total disease remission rate in the observation group was 90.00%,higher than that in the control group(72.50%)(P<0.05).The VAS scores at 3 and 7 days postoperatively were lower in the observation group than in the control group,and the bladder function recovery time and length of hospital stay were shorter in the observation group(all P<0.05).Three months after surgery,the TCM syndrome scores in the observation group were lower than those in the control group(all P<0.05),and the serum levels of CA125,HE4,and IL-6 were lower in the observation group(all P<0.05),while the IL-4 level was higher than that in the control group(P<0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusion:Guizhi Fuling Capsules can effectively reduce levels of tumor markers and inflammatory mediators in patients with early endometrial cancer after laparoscopy,promote postoperative rec
作者
王晓靖
张蓓
戚钰
庞昆
WANG Xiaojing;ZHANG Bei;QI Yu;PANG Kun(Xuzhou Clinical College,Xuzhou Medical University,Xuzhou 221009,China;Xuzhou Central Hospital,Xuzhou 221009,China)
出处
《世界中医药》
CAS
北大核心
2024年第3期373-376,382,共5页
World Chinese Medicine
基金
国家自然科学基金青年科学基金项目(82004110)——葛根素调控ERH表达促进MYC-mRNA降解影响膀胱癌细胞增殖凋亡的分子机制研究。
关键词
子宫内膜癌
桂枝茯苓胶囊
腹腔镜
辅助治疗
肿瘤标志物
炎症介质
术后恢复
Endometrial cancer
Guizhi Fuling Capsules
Laparoscopy
Adjuvant treatment
Tumor marker
Inflammatory media-tor
Postoperative recovery
