摘要
目的:探究新疆北疆地区类风湿关节炎(RA)的中医证候分布规律及其与相关因子的内在关系,为类风湿关节炎的治疗提供帮助。方法:收集北疆地区类风湿关节炎患者217例,对其中医证型、舌苔、脉象、症状、病程、DAS28疾病活动度及用ELISA法测得的IL-1β、BMP6等指标进行统计分析。结果:RA患者女性多于男性,中医证型比例为寒湿痹阻证>肝肾不足证>痰瘀痹阻证>湿热痹阻证>风湿痹阻症>气血两虚证,不同中医证型RA患者性别、年龄分布无统计学差异(P>0.05),该地区RA患者主要证候特点以关节晨僵、关节痛有定处、关节疼痛喜按、遇寒痛增、阴雨天加重、日轻夜重、关节屈伸不利、腰膝酸软、肢体沉重等症状较为常见,不同证型间的病程、DAS28疾病活动度、C反应蛋白、BMP6存在统计学差异(P<0.05),IL-6、IL-1β、RF、抗环瓜氨酸多肽抗体不存在统计学差异(P>0.05)。与其他证型相比,风湿痹阻症的C反应蛋白高于肝肾不足证、寒湿痹阻证的DAS28疾病活动度水平高于肝肾不足证、湿热痹阻证的BMP6水平高于风湿痹阻证、寒湿痹阻证,痰瘀痹阻证BMP6水平高于风湿痹阻证。结论:新疆北疆地区的RA患者中医证候特点以“寒”“湿”“虚”为主,证型以寒湿痹阻证最为多见,且疾病活动度较高,湿热痹阻证及痰瘀痹阻证的骨关节异常表现较为突出,BMP6水平相对较高。年龄和性别对RA的发病有影响,病程长短对RA的中医证型分布有影响。
Objective:To explore the distribution rules of traditional Chinese medicine(TCM)syndromes in patients with rheumatoid arthritis(RA)in the northern Xinjiang region and their inherent relationship with related factors,in order to assistant the clinical treatment of RA.Methods:A total of 217 patients with RA in the northern Xinjiang region were collected.The TCM syndrome types,tongue coating,pulse condition,symptoms,disease duration,disease activity score 28(DAS28),and indicators such as IL-1βand BMP6 detected by ELISA were statistically analyzed.Results:There are more female RA patients than male RA patients.The proportions of TCM syndrome types were as follows:cold-damp obstruction syndrome>liver-kidney deficiency syndrome>phlegm-stasis obstruction syndrome>damp-heat obstruction syndrome>rheumatic obstruction syndrome>qi-blood deficiency syndrome.There was no statistical difference in the distribution of gender and age among different TCM syndrome types in RA patients(P>0.05).The main characteristics of TCM syndromes in this region were morning stiffness of joints,fixed joint pain,joint pain relieved by pressing,increased pain in cold weather,difficulty in joint flexion and extension,soreness and weakness of waist and knees,lighter symptoms during the day and heavier at night,worsened symptoms on rainy days,and heavy limbs.There were statistical differences in disease duration,DAS28,C-reactive protein,and BMP6 among different TCM syndrome types(P<0.05)and no statistical differences in IL-6,IL-1β,RF and CCP(P>0.05).Compared with other syndrome types,the C-reactive protein of wind-dampness impediment was higher than that of deficiency of liver and kidney,the DAS28 disease activity level of cold-dampness impediment was higher than that of deficiency of liver and kidney,the BMP6 level of damp-heat impediment was higher than that of wind-dampness impediment,cold-dampness impediment,and the BMP6 level of phlegm-stasis impediment was higher than that of wind-dampness impediment.Conclusion:The characteristics of traditi
作者
欧阳文柏
张道雨
薛萌萌
刘永丰
唐琪
刘新
OUYANG Wenbo;ZHANG Daoyu;XUE Mengmeng;LIU Yongfeng;TANG Qi;LIU Xin(Xinjiang Medical University,Urumqi 830017,China)
出处
《海南医学院学报》
CAS
北大核心
2024年第8期568-574,共7页
Journal of Hainan Medical University
基金
国家自然科学基金资助项目(81860834)。
关键词
类风湿关节炎
中医证候
骨形态发生蛋白6
Rheumatoid arthritis(RA)
TCM syndrome types
Bone morphogenetic protein 6
