摘要
随着老龄化进程的加快和社会生活方式的转变,老年期抑郁障碍(LLD)的患病率逐年增高。作为最常见的老年期精神障碍,LLD严重影响患者的生活质量,并给家庭和社会带来沉重负担,甚至可能威胁老年患者的生命安全。LLD的发病机制尚不明确,可能是生物、社会和心理多方面因素共同作用所致。由于老年群体的机体功能衰退、共病躯体疾病较多,故对LLD患者的诊治与处理年轻的成年抑郁障碍患者会有所不同。本文对LLD相关的流行病学特征、临床评估和诊断、共病情况以及治疗与干预等方面进行梳理,并着重介绍LLD的药物治疗,以期为临床对LLD的优化诊治和改善预后提供参考。
With the acceleration of the aging process and change in social lifestyle,the prevalence rate of late-life depression(LLD)in the elderly is increasing year by year.As the most common mental disorder in the elderly,LLD seriously affects the quality of life of patients,and thus brings a heavy burden to the family and society.It may even become life-threatening for the elderly patients.The pathogenesis of LLD is still unclear,which may be caused by a combination effects of biological,social and psychological factor.Given the declined body functions and more comorbid physical diseases in the elderly population,the diagnosis and treatment of LLD patients would be different from that of younger adult patients with depression.This paper reviews the epidemiological characteristics,clinical evaluation,diagnosis,comorbidity,treatment and intervention of LLD,and focuses on the selection of therapeutic drugs and adverse reactions,in order to provide references for better diagnosis and treatment of LLD and improve the prognosis of patients.
作者
刘铁桥
Liu Tieqiao(The Second Xiangya Hospital of Central South University,Changsha 410011,China)
出处
《四川精神卫生》
2024年第2期97-101,共5页
Sichuan Mental Health
关键词
老年期抑郁障碍
共病
药物治疗
认知功能
Late-life depression
Comorbidity
Drug therapy
Cognitive function
