摘要
目的观察芪鹿升白方联合聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)治疗肿瘤化疗后中性粒细胞减少症的临床疗效。方法将90例肿瘤化疗后中性粒细胞减少症患者按照随机数字表法分为2组,对照组45例予PEG-rhG-CSF治疗,治疗组45例在对照组的基础上联合芪鹿升白方治疗。2组均治疗3个化疗周期后统计疗效,比较2组治疗前及治疗1、3个化疗周期后中性粒细胞绝对值变化情况,比较2组治疗前及治疗3个化疗周期后症状(包括气短懒言、神疲乏力、心悸失眠、面色萎黄、自汗及头昏眼花,)评分及肝肾功能指标[包括血清肌酐(SCr)、尿素氮(BUN)、天冬氨酸氨基转移酶(AST)及丙氨酸氨基转移酶(ALT)]水平变化情况,并观察2组治疗期间不良反应发生情况。结果与本组治疗前比较,2组治疗1、3个化疗周期后中性粒细胞绝对值均升高(P<0.05),且2组治疗3个化疗周期后中性粒细胞绝对值均高于治疗1个化疗周期时水平(P<0.05),治疗组治疗1、3个化疗周期后中性粒细胞绝对值后水平均高于对照组同期(P<0.05)。与本组治疗前比较,2组治疗3个化疗周期后症状气短懒言、神疲乏力、心悸失眠、面色萎黄、自汗、头昏眼花评分及总分均降低(P<0.05),且治疗组治疗3个化疗周期后各项症状评分及总分均低于对照组(P<0.05)。与本组治疗前比较,2组治疗3个化疗周期后肝肾功能指标SCr、BUN、AST及ALT水平均降低(P<0.05),且治疗组治疗3个化疗周期后SCr、BUN、AST及ALT水平均低于对照组(P<0.05)。治疗组不良反应发生率17.78%(8/45),对照组不良反应发生率11.11%(5/45),2组不良反应发生率比较差异无统计学意义(P>0.05)。结论芪鹿升白方联合PEG-rhG-CSF治疗肿瘤化疗后中性粒细胞减少症患者疗效确切,可有效升高中性粒细胞水平,改善症状和肝肾功能,安全可靠,具有减毒增效的作用。
Objective To explore the curative efficacy of Qilu Shengbai Formula combined with pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)on chemotherapy-associated neutropenia.Methods Ninety patients with chemotherapy-associated neutropenia visited our hospital were gathered and randomly assigned to control group(PEG-rhG-CSF,n=45)and treatment group(Qilu Shengbai Formula plus PEG-rhG-CSF,n=45).The curative effects were statistically analyzed after 3 cycles of chemotherapy.The changes in absolute neutrophil count(ANC),traditional Chinese medicine(TCM)symptoms scores(including short breath and no desire to speak,tiredness,palpitation and insomnia,sallow complexion,spontaneous sweating and dizziness),liver and kidney function indexes(including serum creatinine[SCr],blood urea nitrogen[BUN],aspartate aminotransferase[AST]and alanine aminotransferase[ALT])were included as comparators before treatment and after 1 and 3 cycles of chemotherapy between the two groups.The adverse reactions during treatment were asssessed in the two groups.Results The absolute value of 1-cycle and 3-cycle neutrophils in the two groups was significantly increased than that before treatment(P<0.05),and the absolute value of 3-cycle neutrophils in the two groups was significantly higher than that of 1-cycle(P<0.05).The absolute value of 1-cycle and 3-cycle neutrophils in the treatment group was significantly higher than that in the control group(P<0.05).The 3-cycle dimension score and total score of TCM symptoms were significantly decreased in the two groups than those before treatment(P<0.05),and which were significantly lower in the treatment group than in the control group(P<0.05).The 3-cycle levels of serum BUN,SCr,AST and ALT in the two groups were obviously decreased than those before treatment(P<0.05),and the decrease in the treatment group was more pronounced relative to the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the treatment group and the control
作者
单魁中
黄辉
陆婷婷
任渊
SHAN Kuizhong;HUANG Hui;LU Tingting;REN Yuan(Department of Oncology,Kunshan Second People's Hospital,Kunshan,Jiangsu 215300;Department of Respiratory Medicine,Kunshan Hospital of Traditional Chinese Medicine,Kunshan,Jiangsu 215300)
出处
《河北中医》
2024年第4期566-569,共4页
Hebei Journal of Traditional Chinese Medicine
基金
2020年江苏省基础研究计划(自然科学基金)专项资金项目(编号:BK20200260)。
