摘要
肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)是由肺炎支原体(Mycoplasma pneumoniae,MP)感染引起的呼吸道感染性疾病,是儿童常见的社区获得性肺炎之一。MPP的发病机制可能与MP对宿主直接黏附、损伤以及机体免疫应答紊乱等有关。目前大量研究证实,机体在感染MP后出现的免疫紊乱在MPP的发病中有重要作用。微小RNA(microRNA,miRNA)是一组高度保守的非蛋白编码核苷酸序列,通过调控Th17/Treg比值、核因子-κB、CD4^(+)T/CD8^(+)T比值以及Th1/Th2比值等,参与肺的生长发育、炎性反应及免疫调控等,在MPP的发病机制中发挥重要作用。该文就miRNAs在MPP中的作用机制进行综述,分析miRNAs与MPP发生发展的潜在联系,为临床评估患儿病情及诊疗方案提供参考。
Mycoplasma pneumoniae pneumonia(MPP)is a respiratory infectious diseases caused by Mycoplasma pneumoniae(MP)infection.It is one of the common community-acquired pneumonia in children.The pathogenesis of MPP may be related to the direct adhesion and damage of MP to the host and the disorder of immune response.At present,a large number of studies have confirmed that the immune disorder plays a vital role in the development of MPP.MicroRNA(miRNA)is a group of highly conserved non-protein-coding nucleotide sequences,involved in regulating the Th17/Treg ratio,nuclear factor-κB(NF-κB),CD4^(+)T/CD8^(+)T ratio,and Th1/Th2 ratio to play important roles in lung growth,inflammatory response and immune regulation during the pathogenesis of MPP.This article provides an overview of the mechanism of action of miRNAs in MPP,analyzes the potential connections between miRNAs and the development of MPP,and offers insights for the clinical assessment of children's condition and treatment plans.
作者
那颖
于少飞
朱华
Na Ying;Yu Shaofei;Zhu Hua(Department of Pediatrics,People's Hospital of the Inner Mongolia Autonomous Region,Hohhot 010010,China)
出处
《国际儿科学杂志》
2024年第3期188-192,共5页
International Journal of Pediatrics
基金
内蒙古自治区科学技术厅内蒙古自治区科技计划项目(2023YFSH0042)。
