摘要
目的将反复种植失败(repeated implantation failure,RIF)患者中剩余卵裂胚解冻并培养囊胚移植作为一种潜在的治疗策略,并分析其妊娠结局。方法本研究纳入295名RIF患者进行冻融胚胎移植,根据囊胚来源分为卵裂胚解冻培养囊胚移植组(n=141)和传统解冻囊胚移植组(n=154)。研究两组患者临床妊娠率、种植率和活产率的区别。结果卵裂胚解冻培养囊胚移植组的临床妊娠率、种植率均明显高于传统解冻囊胚移植组(P<0.05),两组之间的流产率、多胎率和活产率差异无统计学意义(P>0.05)。RIF≤4次和RIF=5次的患者,卵裂胚解冻培养囊胚移植组的种植率高于传统的解冻囊胚移植组(P<0.05),而RIF≤4次,RIF=5次和RIF≥6次的患者,两组临床妊娠率、流产率、多胎率和活产率差异均无统计学意义(P均>0.05)。结论当RIF患者囊胚为零时,解冻剩余的卵裂胚并培养囊胚进行移植可以提高临床妊娠率和种植率,是一种有效治疗策略。
Objective To explore the use of remaining cleavage embryo thawing and culturing blastocyst transfer as apotential therapeutic strategy in patients with repeated implantation failure(RIF)and to analyze their pregnancy outcomes.Methods A total of 295 patients with RIF undergoing thawed embryo transfer were included in this study,and they were divided into cleavage embryo thawed and cultured blastocyst transfer group(n=141)and conventional thawed blastocyst transfer group(n=154)according to the source of blastocyst.The clinical pregnancy rate,implantation rate and live birth rate were compared between the two groups.Results The clinical pregnancy rate and the implantation rate of cleavage embryo thawed and cultured blastocyst transfer group were significantly higher than those of conventional thawed blastocyst transfer group(P<0.05),and there were no significant differences in miscarriage rate,multiple birth rate and live birth rate between the two groups(P>0.05).For patients with RIF≤4 times and RIF=5 times,the implantation rate in cleavage embryo thawed and cultured blastocyst transfer group was higher than conventional thawed blastocyst transfer group(P<0.05),however,there were no significant differences in clinical pregnancy rate,miscarriage rate,multiple birth rate and live birth rate among RIF≤4 times,RIF=5 times and RIF≥6 times patients(all P>0.05).Conclusion When there are zero blastocyst in RIF patients,thawing the remaining cleavage embryos and culturing the blastocysts for transfer can improve clinical pregnancy rate and implantation rate,which is an effective treatment strategy.
作者
李翔
曾莠蔓
罗宇迪
杨曾瑜
张炬光
贾俊龙
LI Xiang;ZENG Youman;LUO Yudi;YANG Zengyu;ZHANG Juguang;JIA Junlong(Reroductive Medicine Center,Maternal and Child Health Hospital of Yulin,Yulin Guangxi 573000,China)
出处
《联勤军事医学》
CAS
2024年第2期125-128,共4页
Military Medicine of Joint Logistics
基金
玉林市科技攻关项目(20202001)
兰州市科技局项目(2021-1-100)。
关键词
反复种植失败
剩余卵裂胚
移植策略
妊娠结局
Repeated implantation failure
Remaining cleaved embryo
Transplantation strategy
Pregnancy outcome
