摘要
目的:探究急性肺栓塞采取腔内治疗的效果及对凝血指标的影响。方法:选取2020年10月—2022年10月在山东国欣颐养集团枣庄中心医院治疗的急性肺栓塞患者92例,应用随机数字表法将其分为对照组(n=46)及观察组(n=46)。对照组接受静脉溶栓治疗,观察组接受腔内治疗。对比两组近期疗效、肺动脉高压、肺动脉开通情况(Miller指数)、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肺动脉高压、Miller指数相较,差异均无统计学意义(P>0.05);治疗后,两组肺动脉高压、Miller指数较治疗前均降低,且观察组均低于对照组(P<0.05)。治疗前,两组CRP、IL-6、TNF-α比较,差异均无统计学意义(P>0.05);治疗后,两组CRP、IL-6、TNF-α较治疗前均降低,且观察组均低于对照组(P<0.05)。治疗前,两组PT、APTT、FIB相较,差异均无统计学意义(P>0.05);治疗后,两组PT、APTT较治疗前均延长,FIB均降低,且观察组PT、APTT均长于对照组,FIB低于对照组(P<0.05)。结论:急性肺栓塞患者采取腔内治疗,疗效显著,降低炎症反应,改善凝血功能。
Objective:To explore the effect of intracavitary treatment on acute pulmonary embolism and its impact on coagulation indicators.Method:A total of 92 patients with acute pulmonary embolism treated at Shandong Guoxin Yiyang Group Zaozhuang Central Hospital from October 2020 to October 2022 were selected,they were divided into a control group(n=46)and an observation group(n=46)by random number table method.The control group received intravenous thrombolysis treatment,while the observation group received intracavitary treatment.The recent therapeutic effects,pulmonary hypertension,pulmonary artery patency(Miller index),inflammatory cytokines[C reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)],coagulation function indicators[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]between two groups were compared.Result:The total effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in pulmonary arterial hypertension and Miller index between the two groups(P>0.05);after treatment,pulmonary arterial hypertension and Miller index in both groups decreased compared to those before treatment,and those in the observation group were lower than those in the control group(P<0.05).Before treatment,there were no statistically significant differences in CRP,IL-6,TNF-α between the two groups,the differences were not statistically significant(P>0.05);after treatment,CRP,IL-6,TNF-α of two groups were decreased compared to those before treatment,and those in the observation group were lower than those in the control group(P<0.05).Before treatment,there were no statistically significant differences in PT,APTT and FIB between the two groups(P>0.05);after treatment,PT and APTT of two groups were prolonged compared to those before treatment,while FIB decreased,PT and APTT in the observation group were longer than those in t
作者
陈德文
姚敏
周俊平
CHEN Dewen;YAO Min;ZHOU Junping(Respiratory Medicine,Shandong Guoxin Yiyang Group Zaozhuang Central Hospital,Zaozhuang 277000,China;不详)
出处
《中国医学创新》
CAS
2024年第12期126-130,共5页
Medical Innovation of China
关键词
急性肺栓塞
腔内治疗
静脉溶栓治疗
凝血指标
Acute pulmonary embolism
Intracavitary therapy
Intravenous thrombolytic therapy
Coagulation index
